Activity-Guided Isolation of Saponins from Kalopanaxpictus with Anti-inflammatory Activity
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概要
- 論文の詳細を見る
By bioassay-guided separation, a known saponin, kalopanaxsaponin A (1) and a new saponin, pictoside A (2) were isolated from the stem bark of Kalopanax pictus as anti-inflammatory components when evaluated by vascular permeability test. Another novel saponin, pictoside B (3) was also isolated but was inactive in the test system used. The structures of pictosides A and B were elucidated as caulophyllogenin 3-O-α-_L-rhamnopyranosyl(1→2)-a-_L-arabinopyranoside (2) and pictogenin (3/β,6β,16α,23-tetrahydroxyolean-12-ene-28-oic acid) 3-O-α-_L-arabinopyranoside (3), respectively, by spectral analysis and by chemical degradation. Kalopanaxsaponin A and pictoside A showed significant anti-inflammatory activity at the oral doses of 50 mg/kg.
- 公益社団法人日本薬学会の論文
- 2002-07-01
著者
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KANG Sam
Natural Products Institute, Seoul National University
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Lee Eun
Natural Products Research Institute College Of Pharmacy Seoul National University
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Kang Sam
Natural Products Research Institute Seoul National University
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Kang Sam
Natural Product Research Institute Seoul National University
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Whang Wan
College Of Pharmacy Chung-ang University
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Li Da
Natural Products Research Institute Seoul National University
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HYUN Jin
Natural Products Research Institute, Seoul National University
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Kang S
Natural Products Research Institute And College Of Pharmacy Seoul National University
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Lee Eun
Natural Products Research Center Korea Institute Of Science And Technology (kist) Gangneung Institut
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Lee Eun
Natural Products Research Institute Seoul National University
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Hyun Jin
Natural Products Research Institute Seoul National University
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Kang Sam
Natural Products Research Institute, Seoul National University
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