Anti-inflammatory Activity of Prosapogenin Methyl Ester of Platycodin D via Nuclear Factor-kappaB Pathway Inhibition(Pharmacognosy)
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概要
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Platycodin D (PD) isolated from Platycodi Radix has been reported to have anti-inflammatory and antitumor activities. In this study, we have investigated anti-inflammatory activities of prosapogenin D (PrsD) and prosapogenin D methyl ester (PrsDMe) of PD. The results indicated that PrsDMe concentration-dependently inhibited lipopolysaccharide (LPS)-induced nitric oxide (NO) and prostaglandin E_2 (PGE_2) production, however, PrsD did not inhibit NO production in LPS-induced macrophages. Furthermore, PrsDMe inhibited the expression of inducible nitric oxide synthase (iNOS) and cyclooxygenase-2 (COX-2) without appreciable cytotoxic effects. In the transfectant RAW 264.7 cells, PrsDMe was observed to reduce the level of nuclear factor-κB (NF-κB) activity. PrsDMe also inhibited the degradation of an inhibitory protein called inhibitor κB (IκB). Therefore, it was suggested that PrsDMe inhibited the expression of LPS-induced iNOS and COX-2 genes by suppressing NF-κB activation at the transcriptional level. Also, PrsDMe showed carrageenan-induced acute anti-inflam-matory activity and the adjuvant-induced anti-arthritic activity in mice. In conclusion, we suggest that these compounds exert an anti-inflammatory effect through the regulation of the NF-κB pathway. The different activities of PD, PrsD and PrsDMe are based on the structure of the sugar substituent or methyl group at the C_<28>-car-boxyl position.
- 公益社団法人日本薬学会の論文
- 2008-11-01
著者
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Kim Yeong
Natural Products Research Institute College Of Pharmacy Seoul National University
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Kim Yeong
Natural Products Res. Inst. Coll. Of Pharmacy Seoul National Univ.
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Noh Eun
Natural Products Research Institute College Of Pharmacy Seoul National University
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Lee Eun
Natural Products Research Institute College Of Pharmacy Seoul National University
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Chung Ji
Natural Products Research Institute College Of Pharmacy Seoul National University
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Sim Joon
Natural Products Research Institute College Of Pharmacy Seoul National University:national Institute
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Shin Eun
Natural Products Research Institute College Of Pharmacy Seoul National University
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ZHAO Hai
Natural Products Research Institute, College of Pharmacy, Seoul National University
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Zhao Hai
Natural Products Research Institute College Of Pharmacy Seoul National University
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SIM Joon-Soo
Natural Products Research Institute, College of Pharmacy, Seoul National University
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HA Young
Natural Products Research Institute, College of Pharmacy, Seoul National University
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CHEONG Choon
College of Pharmacy, Duksung Women's University
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Lee E
Seoul National Univ. Seoul Kor
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Cheong Choon
College Of Pharmacy Duksung Women's University
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Ha Young
Natural Products Research Institute College Of Pharmacy Seoul National University
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Lee Eun
Natural Products Research Center Korea Institute Of Science And Technology (kist) Gangneung Institut
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