Anti-obesity Effect of Pinellia ternata Extract in Zucker Rats(Pharmacognosy)
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概要
- 論文の詳細を見る
Pinellia ternata is known as the herb effective in removing dampness-phlegm, one of the causes of obesity in traditional Korean medicine. Pinellia ternata water extract (PE) was fed to rats after mixing with diet once a day (400mg・kg^<-1>) for 6 weeks. We investigated its effect on the thermogenesis and fatty acids oxidation with obese Zucker rats. We also determined the gene expression of uncoupling protein 1 (UCP1), peroxisome proliferators-activated receptor α (PPARα), and PPARγ coactivator 1α (PGC1α). The PE treatment lowered the levels of triglyceride and free fatty acids (p<0.05) in blood of the obese rats and the body weight was also reduced slightly. It was also observed that PE significantly increased the expression of both UCP1 mRNA in brown adipose tissue (BAT) (p<0.001) and PPARα and PGC1α mRNA in white visceral adipose tissue (WAT) (p<0.05 and p<0.001, respectively), which may cause a reduction of obesity. These results suggested that PE would be able to affect anti-obesity through thermogenesis and fatty acid oxidation.
- 公益社団法人日本薬学会の論文
- 2006-06-01
著者
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Kim Yeong
Natural Products Research Institute College Of Pharmacy Seoul National University
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Kim Yeong
Natural Products Res. Inst. Coll. Of Pharmacy Seoul National Univ.
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Lee Sanghyun
Department Of Applied Plant Science Chung-ang University
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Kim Yoo-jeong
Natural Products Research Institute And College Of Pharmacy Seoul National University
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Shin Young-oh
Department Of Sports Medicine Korea National Sport University
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Oh Jae-keun
Department Of Sports Medicine Korea National Sport University
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Lee Sanghyun
Department Of Applied Plant Science College Of Industrial Science Chung-ang University
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HA Young-Wan
Natural Products Research Institute and College of Pharmacy, Seoul National University
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Ha Young-wan
Natural Products Research Institute And College Of Pharmacy Seoul National University
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Shin Young-Oh
Department of Physiology, College of Medicine, Soonchunhyang University
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