Protein Glycation Inhibitors from the Fruiting Body of Phellinus linteus(Pharmacognosy)
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概要
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To characterize active principles for prevention and treatment of diabetic complications, the isolation of protein glycation inhibitors from the fruiting body of Phellinus linteus was conducted in vitro using the model systems of hemoglobin-δ-gluconolactone (early stage), bovine serum albumin-methylglyoxal (middle stage), and N^α-acetyl-glycyl-lysine methyl ester-D-ribose (last stage) assays. Nine compounds were isolated from the active ethylacetate fraction of the fruiting body and identified as protocatechuic acid (1), protocatechualdehyde (2), caffeic acid (3), ellagic acid (4), hispidin (5), davallialactone (6), hypholomine B (7), interfungins A (8), and inoscavin A (9) by spectroscopic analyses. At the early stage of protein glycation, compounds 6, 8, and 9 exhibited inhibitory activity on hemoglobin A_<1C> formation. For the middle stage, compounds 2, 6, and 9 showed a significant inhibitory effect on methylglyoxal-medicated protein modification and their IC_<50> values were 144.28, 213.15,and 158.66μM, respectively. At the last stage of glycation, compound 8 was found to be a potent inhibitor of the cross-linking of proteins, which was more effective than that of aminoguanidine, a well-known inhibitor for advanced glycation end products. Consequently, compound 8 showed the most potent inhibitory effects at each stage of protein glycation. This mechanism may help to provide a protective effect against hyperglycemia-mediated protein damage.
- 社団法人日本薬学会の論文
- 2008-10-01
著者
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Lim Soon
Department of Food Science and Nutrition, Hallym University
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PARK Jung
Department of East-West Medicine, Graduate School, Kyung Hee University
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Lee Sanghyun
韓国
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Lee Sang
College Of Industrial Science Chung-ang University
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Shin Hyun-kyung
Department Of Food Science And Nutrition Hallym University:regional Innovation Center Hallym Univers
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Shin Hyun-kyung
韓国
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Lim Soon
Dep. Of Food Sci. And Nutrition Hallym Univ.
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Lim Soon
韓国
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Lim Soon
Department Of Food Science And Nutrition Silver Biotechnology Research Center Hallym University
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Lee Sanghyun
Department Of Applied Plant Science Chung-ang University
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Lee Yeon
Center For Efficacy Assessment And Dev. Of Functional Foods And Drugs Hallym Univ.
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Kang Young-hee
Department Of Food Science And Nutrition Hallym University
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Ban Hyun
Center For Efficacy Assessment And Dev. Of Functional Foods And Drugs Hallym Univ.
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LEE Yeon
Department of Biological Sciences, KAIST
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Lim Soon
Department Of Food Science And Nutrition Hallym University:regional Innovation Center Hallym Univers
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JUNG Ju-Young
College of Veterinary Medicine, Chungnam National University
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OHUCHI Kazuo
Faculty of Pharmacy, Yasuda Women's University
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SHIN Kuk
Korea Institute of Science and Technology Information
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KANG Il-Jun
Department of Food Science and Nutrition, Hallym University
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Park Jung
Department Of Food Science And Nutrition Silver Biotechnology Research Center Hallym University
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Kang Il-jun
Department Of Food Science And Nutrition Hallym University
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Jung Ju-young
College Of Veterinary Medicine Chungnam National University
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Park Jung
Department Of Food Science And Nutrition Hallym University
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Ohuchi Kazuo
Faculty Of Pharmacy Yasuda Women's University
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Park Jung
Department Of Chemistry Gyeongsang National University
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Park Jung
Department Electrical Engineering Busan National University
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Lee Yeon
Department Of Food Science And Nutrition Hallym University
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Lee Yeon
Department Of Biological Sciences Kaist
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Lim Soon
Department of Food and Nutrition, Hallym University
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Lee Yeon
Department of Applied Plant Science, Chung-Ang University
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Kang Young-Hee
Department of Food and Nutrition, Hallym University
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