Xanthorrhizol, a Natural Sesquiterpenoid, Induces Apoptosis and Growth Arrest in HCT116 Human Colon Cancer Cells
スポンサーリンク
概要
- 論文の詳細を見る
Xanthorrhizol is a sesquiterpenoid from the rhizome of Curcuma xanthorrhiza. In our previous studies, xanthorrhizol suppressed cyclooxygenase-2 (COX-2) and inducible nitric oxide synthase (iNOS) expression, inhibited cancer cell growth, and exerted an anti-metastatic effect in an animal model. However, the exact mechanisms for its inhibitory effects against cancer cell growth have not yet been fully elucidated. In the present study, we investigated the growth inhibitory effect of xanthorrhizol on cancer cells. Xanthorrhizol dose-dependently exerted antiproliferative effects against HCT116 human colon cancer cells. Xanthorrhizol also arrested cell cycle progression in the G0/G1 and G2/M phase and induced the increase of sub-G1 peaks. Cell cycle arrest was highly correlated with the downregulation of cyclin A, cyclin B1, and cyclin D1; cyclin-dependent kinase 1 (CDK1), CDK2, and CDK4; proliferating cell nuclear antigen; and inductions of p21 and p27, cyclin-dependent kinase inhibitors. The apoptosis by xanthorrhizol was markedly evidenced by induction of DNA fragmentation, release of cytochrome c, activation of caspases, and cleavage of poly-(ADP-ribose) polymerase. In addition, xanthorrhizol increased the expression and promoter activity of pro-apoptotic non-steroidal anti-inflammatory drug–activated gene-1 (NAG-1). These findings provide one plausible mechanism for the growth inhibitory activity of xanthorrhizol against cancer cells.
- 社団法人 日本薬理学会の論文
- 2009-11-20
著者
-
Chung Won-Yoon
Department of Oral Biology, Yonsei University College of Dentistry
-
PARK Kwang-Kyun
Department of Oral Biology, Yonsei University College of Dentistry
-
Park Kwang-kyun
Dep. Of Oral Biology Yonsei Univ. Coll. Of Dentistry
-
Park Kwang-kyun
College Of Dentistry Yonsei University
-
Lee Sang
College Of Industrial Science Chung-ang University
-
Chung Won-yoon
Oral Cancer Res. Inst. Oral Sci. Res. Inst. And Brain Korea 21 Project Yonsei Univ. Coll. Of Dentist
-
HWANG Jae-Kwan
Department of Biotechnology, Yonsei University
-
Hwang Jae-kwan
Department Of Biotechnology Yonsei University
-
Hwang Jae-kwan
Department Of Biomaterials Science And Engineering Yonsei University
-
Lee Sang
College Of Pharmacy Ewha Womans University
-
KANG You-Jin
College of Pharmacy, Ewha Womans University
-
CHUNG Won-Yoon
College of Dentistry, Yonsei University
-
Kang You-jin
College Of Pharmacy Ewha Womans University
-
Chung Won-yoon
College Of Dentistry Yonsei University
-
Lee Sang
College Of Agriculture And Life Sciences Kyungpook National University
関連論文
- Hepatotoxicity and Immunotoxicity of 1-Bromohexane and Its Glutathione Conjugation in Female BALB/c Mice
- Honokiol Inhibits the Progression of Collagen-Induced Arthritis by Reducing Levels of Pro-inflammatory Cytokines and Matrix Metalloproteinases and Blocking Oxidative Tissue Damage
- Red Ginseng Saponin Extract Attenuates Murine Collagen-Induced Arthritis by Reducing Pro-inflammatory Responses and Matrix Metalloproteinase-3 Expression
- Aldose Reductase Inhibitory Compounds from Glycyrrhiza uralensis
- Pleurospermum kamtschaticum Extract Induces Apoptosis via Mitochondrial Pathway and NAG-1 Expression in Colon Cancer Cells
- Effects of Panduratin A Isolated from Kaempferia pandurata ROXB : on the Expression of Matrix Metalloproteinase-9 by Porphyromonas gingivalis Supernatant-Induced KB Cells(Biopharmacy)
- Depigmentation of Melanocytes by Isopanduratin A and 4-Hydroxypanduratin A Isolated from Kaempferia pandurata ROXB(Biopharmacy)
- Inhibition of Aldose Reductase by Phenylethanoid Glycoside Isolated from the Seeds of Paulownia coreana
- Protective Effect of (4-Methoxybenzylidene)-(3-methoxynophenyl)amine against Neuronal Cell Death Induced by Oxygen and Glucose Deprivation in Rat Organotypic Hippocampal Slice Culture(Medicinal Chemistry)
- Identification of a New Cytotoxic Biflavanone from Selaginella doederleinii
- Identification of a New Naphthalene and Its Derivatives from the Bulb of Eleutherine americana with Inhibitory Activity on Lipopolysaccharide-Induced Nitric Oxide Production
- Growth Inhibition and Induction of G1 Phase Cell Cycle Arrest in Human Lung Cancer Cells by a Phenylbutenoid Dimer Isolated from Zingiber cassumunar(Pharmacology)
- Cyclooxygenase-2 Inhibitory Phenylbutenoids from the Rhizomes of Zingiber cassumunar
- Humulene Derivatives from Zingiber zerumbet with the Inhibitory Effects on Lipopolysaccharide-Induced Nitric Oxide Production
- Protein Glycation Inhibitors from the Fruiting Body of Phellinus linteus(Pharmacognosy)
- Inhibitory Effects of Isorhamnetin-3-O-β-D-glucoside from Salicornia herbacea on Rat Lens Aldose Reductase and Sorbitol Accumulation in Streptozotocin-Induced Diabetic Rat Tissues(Pharmacognosy)
- The mechanism of anti-inflammatory activity of 2'-hydroxychalcone derivatives
- Cytotoxicity and DNA Topoisomerase Inhibitory Activity of Benz[f]indole-4,9-dione Analogs(Biochemistry & Molecular Biology)
- Pharmacologically Active Saikosaponin in Bupleurum falcatum Detected by Competitive ELISA and Eastern Blotting Using Monoclonal Antibodies(Crop Physiology & Ecology)
- Eastern blotting and use of anti-saikosaponin a monoclonal antibodies for detection of saikosaponins
- Daphnane Diterpene Esters with Anti-proliferative Activities against Human Lung Cancer Cells from Daphne genkwa
- Metabolism of FPP-3, an Anti-inflammatory Propenone Compound, in Rat by Liquid Chromatography-Electrospray Ionization Tandem Mass Spectrometry(Biopharmacy)
- Determination of 1-furan-2-yl-3-pyridin-2-yl-propenone, an anti-inflammatory propenone compound, by high performance liquid chromatography with ultraviolet spectrometry
- The Effect of 1-Furan-2-yl-3-pyridine-2-yl-propenone on Pharmacokinetic Parameters of Theophylline(Biopharmacy)
- Xanthorrhizol, a Natural Sesquiterpenoid, Induces Apoptosis and Growth Arrest in HCT116 Human Colon Cancer Cells
- Estrogenic Activity of Xanthorrhizol Isolated from Curcuma xanthorrhiza ROXB.
- Aldose Reductase Inhibitors from the Fruiting Bodies of Ganoderma applanatum(Pharmacognosy)
- Geniposide from Gardenia jasminoides Attenuates Neuronal Cell Death in Oxygen and Glucose Deprivation-Exposed Rat Hippocampal Slice Culture(Pharmacognosy)
- Inhibitory Effects of Ethaverine, a Homologue of Papaverine, on Monoamine Oxidase Activity in Mouse Brain
- The effect of 4-hydroxypanduratin A on the mitogen-activated protein kinase-dependent activation of matrix metalloproteinase-1 expression in human skin fibroblasts
- Macelignan Inhibits Melanosome Transfer Mediated by Protease-Activated Receptor-2 in Keratinocytes
- Nuclear Factor E2–Related Factor 2–Mediated Induction of NAD(P)H:Quinone Oxidoreductase 1 by 3,5-Dimethoxy-trans-stilbene
- Protective Effects of Macelignan on Cisplatin-Induced Hepatotoxicity Is Associated with JNK Activation(Biopharmacy)
- Ginsenoside 20(S)-Protopanaxatriol (PPT) Activates Peroxisome Proliferator-Activated Receptor γ (PPARγ) in 3T3-L1 Adipocytes(Pharmacology)
- Testosterone 5α-Reductase Inhibitors, Menaquinone 7 Produced by a Bacillus and Phenazine Methosulfate
- Suppressive effect of ethanolic Kaempferia pandurata Roxb. extract on matrix metalloproteinase-2 expression in Porphyromonas gingivalis-treated human gingival fibroblasts in vitro
- Inhibitory Effect of Panduratin A on c-Jun N-Terminal Kinase and Activator Protein-1 Signaling Involved in Porphyromonas gingivalis Supernatant-Stimulated Matrix Metalloproteinase-9 Expression in Human Oral Epidermoid Cells
- Comparative Molecular Field Analysis Study of Stilbene Derivatives Active against A549 Lung Carcinoma
- Antioxidant Properties of Neohesperidin Dihydrochalcone : Inhibition of Hypochlorous Acid-Induced DNA Strand Breakage, Protein Degradation, and Cell Death(Medicinal Chemistry)
- Effects of macelignan isolated from Myristica fragrans Houtt. on UVB-induced matrix metalloproteinase-9 and cyclooxygenase-2 in HaCaT cells
- Pleurospermum kamtschaticum Extract Induces Apoptosis via Mitochondrial Pathway and NAG-1 Expression in Colon Cancer Cells
- Inhibitory Effects of Macelignan Isolated from Myristica fragrans HOUTT. on Melanin Biosynthesis(Miscellaneous)
- Immunostimulating Activity of Crude Polysaccharide Extract Isolated from Curcuma xanthorrhiza Roxb
- Immunostimulating Activity of Crude Polysaccharide Extract Isolated from Curcuma xanthorrhiza Roxb.
- Magnolol Suppresses Metastasis via Inhibition of Invasion, Migration, and Matrix : Metalloproteinase-2/-9 Activities in PC-3 Human Prostate Carcinoma Cells
- Effects of (+)-Catechin on the Function of Osteoblastic Cells
- Asperlin From the Marine-Derived Fungus Aspergillus sp. SF-5044 Exerts Anti-inflammatory Effects Through Heme Oxygenase-1 Expression in Murine Macrophages
- meso-Dihydroguaiaretic Acid Inhibits Hepatic Lipid Accumulation by Activating AMP-Activated Protein Kinase in Human HepG2 Cells
- In Vitro Antibacterial Activity of Panduratin A against Enterococci Clinical Isolates
- Identification of a Tryptanthrin Metabolite in Rat Liver Microsomes by Liquid Chromatography/Electrospray Ionization-Tandem Mass Spectrometry(Biopharmacy)
- Honokiol Inhibits the Progression of Collagen-Induced Arthritis by Reducing Levels of Pro-inflammatory Cytokines and Matrix Metalloproteinases and Blocking Oxidative Tissue Damage
- Nuclear Factor E2-Related Factor 2-Mediated Induction of NAD(P)H : Quinone Oxidoreductase 1 by 3,5-Dimethoxy-trans-stilbene
- Asperlin From the Marine-Derived Fungus Aspergillus sp. SF-5044 Exerts Anti-inflammatory Effects Through Heme Oxygenase-1 Expression in Murine Macrophages
- Diversity and community structure of ectomycorrhizal fungi in Pinus thunbergii coastal forests in the eastern region of Korea
- Effects of Macelignan Isolated from Myristica fragrans (Nutmeg) on Expression of Matrix Metalloproteinase-1 and Type I Procollagen in UVB-Irradiated Human Skin Fibroblasts
- Ectomycorrhizal fungal community associated with naturally regenerating Pinus densiflora Sieb. et Zucc. seedlings on exposed granite slopes along woodland paths
- Kalopanaxsaponin A Inhibits the Invasion of Human Oral Squamous Cell Carcinoma by Reducing Metalloproteinase-9 mRNA Stability and Protein Trafficking
- Nucleophilic Activation of a Tetra-Substituted Mitomycin Cyclic Bis-Disulfide
- Activity of panduratin A isolated from Kaempferia pandurata Roxb. against multi-species oral biofilms in vitro
- Improved Skin Delivery of Voriconazole with a Nanostructured Lipid Carrier-Based Hydrogel Formulation