Depigmentation of Melanocytes by Isopanduratin A and 4-Hydroxypanduratin A Isolated from Kaempferia pandurata ROXB(Biopharmacy)
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概要
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This study was carried out to investigate the in vitro effects of isopanduratin A and 4-hydroxypanduratin A isolated from Kaempferia pandurata ROXB. on melanin biosynthesis and tyrosinase activity. Two chalcone compounds, isopanduratin A and 4-hydroxypanduratin A, were isolated from the ethyl acetate fraction of ethanol extract as the active principles. Compared with phenylthiourea (IC_<50>=34.3μM) as a positive control, the depigmentation IC_<50> values for isopanduratin A and 4-hydroxypanduratin A were 10.6μM and 23.2μM, respectively. The compounds also significantly inhibited the activity of tyrosinase, the enzyme that converts DOPA (3, 4-dihydroxy-phenylalanine) to dopachrome in the biosynthetic process of melanin. The IC_<50> values of isopanduratin A and 4-hydroxypanduratin A for tyrosinase were 10.5μM and >30μM, respectively, while that of phenylthiourea was 47.6μM. The tyrosinase protein level was also significantly decreased by isopanduratin A and 4-hydroxypanduratin A. The results indicate that isopanduratin A and 4-hydroxypanduratin A isolated from K. pandurata ROXB. are promising compounds that could be useful for treating hyperpigmentation as skin-whitening agents.
- 社団法人日本薬学会の論文
- 2007-11-01
著者
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Baek Nam-in
Department Of Oriental Medicinal Materials And Processing Kyunghee University
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YOON Ji-Hoon
Department of Biotechnology, Yonsei University
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SHIM Jae-Seok
Department of Biotechnology, Yonsei University
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CHO Yumi
Department of Biotechnology, Yonsei University
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LEE Chan-Woo
R&D Center, Amore-Pacific Corporation
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KIM Han-Sung
R&D Center, Amore-Pacific Corporation
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HWANG Jae-Kwan
Department of Biotechnology, Yonsei University
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Yoon Ji-hoon
Department Of Biotechnology Yonsei University
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Cho Yumi
Department Of Biotechnology Yonsei University
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Lee Chan-woo
R&d Center Amore-pacific Corporation
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Kim Han-sung
R&d Center Amore-pacific Corporation
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Shim Jae-seok
Department Of Biotechnology Yonsei University
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Shim Jae-seok
Department Of Biomaterials Science And Engineering Yonsei University
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Hwang Jae-kwan
Department Of Biotechnology Yonsei University
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Hwang Jae-kwan
Department Of Biomaterials Science And Engineering Yonsei University
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Hwang Jae-kwan
Department Of Biotechnology & Bioproducts Research Center Yonsei University
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