Effects of (+)-Catechin on the Function of Osteoblastic Cells
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概要
- 論文の詳細を見る
Tumor necrosis factor-a (TNF-a) and interleukin-6 (IL-6) are candidate cytokines which are produced by osteoblastic linage cells and promote osteoblast apoptosis, osteoclastogenesis and bone resorption. Here, we examined the effect of (+)-catechin, one of the most common grape flavonols, on osteoblastic MC3T3-E1 cells. (+)- Catechin caused a significant elevation of cell survival at 10^5 and 10^4M and alkaline phosphatase activity at 10^5M. Also, treatment with (+)-cateehin (10^5M) decreased bone-resorbing cytokines (TNF-a and IL-6) production and apoptosis in osteoblasts. Our data indicate that the reduction of bone-resorbing cytokines and apoptosis in osteoblasts by (+)-catechin may result in the prevention and therapy for osteoporosis and inflammatory bone diseases.
- 公益社団法人日本薬学会の論文
- 2003-04-01
著者
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Choi Eun-mi
Coll. Of Pharmacy Chungnam National Univ. Kor
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Choi Eun
Coll. Of Pharmacy Chungnam National Univ.
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HWANG Jae-Kwan
Department of Biotechnology, Yonsei University
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Choi Eun-mi
Department Of Biotechnology & Bioproducts Research Center Yonsei University
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Hwang Jae-kwan
Department Of Biotechnology Yonsei University
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Hwang Jae-kwan
Department Of Biomaterials Science And Engineering Yonsei University
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Hwang Jae-kwan
Department Of Biotechnology & Bioproducts Research Center Yonsei University
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