Biochanin A Stimulates Osteoblastic Differentiation and Inhibits Hydrogen Peroxide-Induced Production of Inflammatory Mediators in MC3T3-E1 Cells(Biopharmacy)

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概要

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• Phytoestrogens are plant chemicals that are structurally analogous to estrogen and are known to affect estrogenic activity. Biochanin A, a naturally occurring isoflavone, has been identified and detected in various diets and plant species. We examined the effects of biochanin A on the differentiation of osteoblastic MC3T3-E1 cells and the production of local factors in osteoblasts. Biochanin A (1-50μM) caused a significant elevation of cell growth, alkaline phosphatase (ALP) activity, collagen content, and osteocalcin secretion in osteoblastic MC3T3-E1 cells (p<0.05). The effect of biochanin A (10μM) in increasing ALP activity and collagen content was completely prevented by the presence of 10^<-6>M cycloheximide and 10^<-6>M tamoxifen, suggesting that biochanin A's effect results from a newly synthesized protein component and might be partly involved in estrogen action. We then examined the effect of biochanin A on the H_2O_2-induced production of inflammatory mediators in osteoblasts. Biochanin A (1-10μM) decreased the 0.2mM H_2O_2-induced production of TNF-α, IL-6 and NO in osteoblasts. These results suggest that biochanin A may be useful as potential phytoestrogens, which play important physiological roles in the prevention of postmenopausal osteoporosis.

• 公益社団法人日本薬学会の論文
• 2005-10-01

著者

• LEE KYUNG

  Department of Pediatrics, The Catholic University of Korea

• CHOI Eun

  Department of Internal Medicine, Cheju National University College of Medicine

• Choi Eun-mi

  Coll. Of Pharmacy Chungnam National Univ. Kor

• Choi Eun

  Coll. Of Pharmacy Chungnam National Univ.

• Lee Kyung

  Department Of Anesthesia And Pain Medicine Gachon University Of Medicine And Science Gil Medical Cen

• Choi Eun-mi

  Department Of Biotechnology & Bioproducts Research Center Yonsei University

• Choi Eun

  Department Of Electrophysics Charged Particle Beam And Plasma Laboratory

• Choi Eun

  Department Of Food & Nutrition Kyung Hee University

• Lee Kyung

  Department Of Food Service Management College Of Hotel And Tourism Management Kyung Hee University

• Lee Kyung

  Department Of Agricultural Chemistry Division Of Applied Life Science Gyeongsang National University

• Lee Kyung-Hee

  Department of Food Service Management, College of Hotel and Tourism Management, Kyung Hee University

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