Ginsenoside 20(S)-Protopanaxatriol (PPT) Activates Peroxisome Proliferator-Activated Receptor γ (PPARγ) in 3T3-L1 Adipocytes(Pharmacology)
スポンサーリンク
概要
- 論文の詳細を見る
Peroxisome proliferator-activated receptor γ (PPARγ), a member of the nuclear receptor of ligand-activated transcription factors, regulates the expression of key genes involved in lipid and glucose metabolism or adipocyte differentiation. Ligands for this receptor have emerged as potent insulin sensitizers used in the treatment of Type2 diabetes. Ginseng saponins or ginsenosides are reported to provide anti-diabetic activity as well as to modulate glucose metabolism, although the mechanism remains unclear. In this study, we examined the effect of gin-senosides on activation of PPARγ and adipogenes in 3T3-L1. Using a GAL-4/PPARγ transactivation assay, 20(S)-protopanaxatriol (PPT), one of the ginsenoside metabolites, was found to increase PPARγ-transactivation activity dose-dependently with similar activity as troglitazone, a well-known PPARγ agonist. PPT enhanced adipogenesis by increasing the expression of PPARγ target genes such as aP2, LPL and PEPCK. Furthermore, PPT significantly increased expression of glucose transporter 4 (GLUT4). These results indicate that PPT can be developed as a PPARγ agonist for the improvement of insulin resistance associated with diabetes.
- 公益社団法人日本薬学会の論文
- 2006-01-01
著者
-
HWANG Jae-Kwan
Department of Biotechnology, Yonsei University
-
Sohn Jong
Department Of Applied Chemistry Engineering College Kyungpook National University
-
Hwang Jae-kwan
Department Of Biotechnology Yonsei University
-
Hwang Jae-kwan
Department Of Biomaterials Science And Engineering Yonsei University
-
Hwang Jae-kwan
Department Of Biotechnology & Bioproducts Research Center Yonsei University
-
HAN Kyu
Department of Anesthesiology and Pain Medicine, Chungnam National University Hospital
-
Han Kyu
Department Of Biotechnology Yonsei University
-
Han Kyu
Department Of Anesthesiology And Pain Medicine Chungnam National University Hospital
-
Sohn Jong
韓国
-
JUNG Myeong
Division of Metabolic Disease, Department of Biomedical Science, National Institute of Health
-
Jung Myeong
Division Of Metabolic Disease Department Of Biomedical Science National Institute Of Health
-
HAN Kyu
Department of Biotechnology, Yonsei University
関連論文
- Effects of Panduratin A Isolated from Kaempferia pandurata ROXB : on the Expression of Matrix Metalloproteinase-9 by Porphyromonas gingivalis Supernatant-Induced KB Cells(Biopharmacy)
- Glycoprotein Isolated from Acanthopanax senticosus Protects against Hepatotoxicity Induced by Acute and Chronic Alcohol Treatment(Pharmacognosy)
- Depigmentation of Melanocytes by Isopanduratin A and 4-Hydroxypanduratin A Isolated from Kaempferia pandurata ROXB(Biopharmacy)
- Protective Effects of Panduratin A against Oxidative Damage of tert-Butylhydroperoxide in Human HepG2 Cells(Pharmacology)
- Pretreatment with nafamostat mesilate, a kallikrein inhibitor, to decrease withdrawal response associated with rocuronium
- Xanthorrhizol, a Natural Sesquiterpenoid, Induces Apoptosis and Growth Arrest in HCT116 Human Colon Cancer Cells
- Estrogenic Activity of Xanthorrhizol Isolated from Curcuma xanthorrhiza ROXB.
- The effect of 4-hydroxypanduratin A on the mitogen-activated protein kinase-dependent activation of matrix metalloproteinase-1 expression in human skin fibroblasts
- Macelignan Inhibits Melanosome Transfer Mediated by Protease-Activated Receptor-2 in Keratinocytes
- Protective Effects of Macelignan on Cisplatin-Induced Hepatotoxicity Is Associated with JNK Activation(Biopharmacy)
- Ginsenoside 20(S)-Protopanaxatriol (PPT) Activates Peroxisome Proliferator-Activated Receptor γ (PPARγ) in 3T3-L1 Adipocytes(Pharmacology)
- Wound Healing Fibroblasts Modulate Corneal Angiogenic Privilege : Interplay of Basic Fibroblast Growth Factor and Matrix Metalloproteinases in Corneal Angiogenesis
- Suppressive effect of ethanolic Kaempferia pandurata Roxb. extract on matrix metalloproteinase-2 expression in Porphyromonas gingivalis-treated human gingival fibroblasts in vitro
- Inhibitory Effect of Panduratin A on c-Jun N-Terminal Kinase and Activator Protein-1 Signaling Involved in Porphyromonas gingivalis Supernatant-Stimulated Matrix Metalloproteinase-9 Expression in Human Oral Epidermoid Cells
- Antioxidant Properties of Neohesperidin Dihydrochalcone : Inhibition of Hypochlorous Acid-Induced DNA Strand Breakage, Protein Degradation, and Cell Death(Medicinal Chemistry)
- Effects of macelignan isolated from Myristica fragrans Houtt. on UVB-induced matrix metalloproteinase-9 and cyclooxygenase-2 in HaCaT cells
- Inhibitory Effects of Macelignan Isolated from Myristica fragrans HOUTT. on Melanin Biosynthesis(Miscellaneous)
- Immunostimulating Activity of Crude Polysaccharide Extract Isolated from Curcuma xanthorrhiza Roxb
- Immunostimulating Activity of Crude Polysaccharide Extract Isolated from Curcuma xanthorrhiza Roxb.
- Effects of (+)-Catechin on the Function of Osteoblastic Cells
- meso-Dihydroguaiaretic Acid Inhibits Hepatic Lipid Accumulation by Activating AMP-Activated Protein Kinase in Human HepG2 Cells
- The Effect of Al2O3 Addition on Catalytic Activities of NiSO4/Al2O3-ZrO2 for Acid Catalysis
- In Vitro Antibacterial Activity of Panduratin A against Enterococci Clinical Isolates
- A New Solid Superacid Catalyst Prepared by Doping ZrO_2 with Ce and Modifying with Sulfate Simultaneously
- Effects of Macelignan Isolated from Myristica fragrans (Nutmeg) on Expression of Matrix Metalloproteinase-1 and Type I Procollagen in UVB-Irradiated Human Skin Fibroblasts
- Activity of panduratin A isolated from Kaempferia pandurata Roxb. against multi-species oral biofilms in vitro