Glycoprotein Isolated from Acanthopanax senticosus Protects against Hepatotoxicity Induced by Acute and Chronic Alcohol Treatment(Pharmacognosy)

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概要

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• The protective effect of a 30 kDa glycoprotein (GF-AS) isolated from the stem bark of Acanthopanax senticosus against acute and chronic alcohol-induced hepatotoxicity were studied. N-terminal amino acid sequence of GF-AS showed NH_2-Val-Ala-Tyr-Pro-Trp-Ala-Gly-Phe-Ala-Leu-Ser-Leu-Glx-Pro-Pro-Ala-Gly-Tyr-. GF-AS significantly increases the activities of alcohol-metabolizing enzymes, including alcohol dehydrogenase, microsomal ethanol metabolizing system, and acetaldehyde dehydrogenase in rats acutely treated with alcohol, resulting in decreased plasma alcohol levels. GF-AS also increases the activities of antioxidant enzymes and glutathione level. Markers of liver injury induced by alcohol: elevated serum levels of aspartate aminotransferase, alanine aminotransferase, triglyceride and cholesterol, are reduced by GF-AS in both acutely and chronically treated rats. The activities of lipogenic enzymes including malic enzyme, glucose-6-phosphate dehydrogenase, and 6-phosphoglucuronic acid dehydrogenase in chronic alcohol-treated rats are significantly decreased by GF-AS. Furthemore, GF-AS improves histological change in fatty liver and hepatic lesions induced by alcohol. Collectively, GF-AS may alleviate alcohol-induced hepatotoxicity through increasing ethanol and lipid metabolism, as well as antioxidant defense systems in livers injured by acute- and chronic-alcohol treatment.

• 2006-02-01

著者

• KIM Won

  Division of Applied Science, Cheongju University

• Choi Joo

  Division Of Metabolic Disease Department Of Biomedical Sciences National Institute Of Health

• Kang Kyung

  Division of Cardiology, Chonnam National University Hospital

• Suh Young

  Division Of Metabolic Disease Department Of Biomedical Sciences National Institute Of Health

• Yoon Taek

  Bio-food And Drug Research Center Kun-kuk University

• Kim Won

  Division Of Metabolic Disease Department Of Biomedical Sciences National Institute Of Health

• Lee Kyeong

  Kolon Central Research Park

• JUNG Myeong

  Division of Metabolic Disease, Department of Biomedical Science, National Institute of Health

• SONG Jihyun

  Division of Metabolic Disease, Department of Biomedical Sciences, National Institute of Health

• Jung Myeong

  Division Of Metabolic Disease Department Of Biomedical Sciences National Institute Of Health

• Jung Myeong

  Division Of Metabolic Disease Department Of Biomedical Science National Institute Of Health

• Song Jihyun

  Division Of Metabolic Disease Department Of Biomedical Sciences National Institute Of Health

• Kang Kyung

  Division Of Breast And Endocrine Surgery Hallym University Sacred Heart Hospital College Of Medicine

• Kang Kyung

  Division Of Metabolic Disease Department Of Biomedical Sciences National Institute Of Health

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