Effects of Macelignan Isolated from Myristica fragrans (Nutmeg) on Expression of Matrix Metalloproteinase-1 and Type I Procollagen in UVB-Irradiated Human Skin Fibroblasts
スポンサーリンク
概要
- 論文の詳細を見る
Exposure to ultraviolet (UV) light causes premature skin aging that is associated with upregulated matrix metalloproteinases (MMPs) and decreased collagen synthesis. Macelignan, a natural lignan compound isolated from Myristica fragrans HOUTT. (nutmeg), has been reported to possess antioxidant and antiinflammatory activities. This study assessed the effects of macelignan on photoaging and investigated its mechanisms of action in UV-irradiated human skin fibroblasts (Hs68) by reverse transcription-polymerase chain reaction, Western blot analysis, 2′,7′-dichlorofluorescein diacetate assay, and enzyme-linked immunosorbent assay. Our results show that macelignan attenuated UV-induced MMP-1 expression by suppressing phosphorylation of mitogen-activated protein kinases (MAPKs) induced by reactive oxygen species. Macelignan also increased type I procollagen expression and secretion through transforming growth factor β (TGF-β)/Smad signaling. These findings indicate that macelignan regulates the expression of MMP-1 and type I procollagen in UV-irradiated human skin fibroblasts by modulating MAPK and TGF-β/Smad signaling, suggesting its potential as an efficacious antiphotoaging agent.
著者
-
Kim Myung-suk
Department Of Pharmacology Seoul National University College Of Medicine
-
HWANG Jae-Kwan
Department of Biotechnology, Yonsei University
-
Hwang Jae-kwan
Department Of Biomaterials Science And Engineering Yonsei University
-
Lee Kyung-eun
Department Of Electronics Engineering Sejong University
-
Mun Sukyeong
Department of Biotechnology, Yonsei University
-
Pyun Hee-Bong
Department of Biomaterial Science and Engineering, Yonsei University
-
Lee Kyung-Eun
Department of Biotechnology, College of Life Science and Biotechnology, Yonsei University
-
Lee Kyung-Eun
Department of Biotechnology, Yonsei University
-
Kim Myung-Suk
Department of Biotechnology, Yonsei University
関連論文
- Effects of Panduratin A Isolated from Kaempferia pandurata ROXB : on the Expression of Matrix Metalloproteinase-9 by Porphyromonas gingivalis Supernatant-Induced KB Cells(Biopharmacy)
- Depigmentation of Melanocytes by Isopanduratin A and 4-Hydroxypanduratin A Isolated from Kaempferia pandurata ROXB(Biopharmacy)
- Protective Effects of Epicatechin Against the Toxic Effects of Streptozotocin on Rat Pancreatic Islets : In Vivo and in Vitro
- Site-Specific Distribution of Phospholipase D Isoforms in the Rat Pancreas
- Effect of Somatostatin on Cholecystokinin-Induced Amylase Release in Rat Pancreatic Acini
- Distributional Patterns of Phospholipase C Isozymes in Rat Pancreas
- Xanthorrhizol, a Natural Sesquiterpenoid, Induces Apoptosis and Growth Arrest in HCT116 Human Colon Cancer Cells
- Estrogenic Activity of Xanthorrhizol Isolated from Curcuma xanthorrhiza ROXB.
- The effect of 4-hydroxypanduratin A on the mitogen-activated protein kinase-dependent activation of matrix metalloproteinase-1 expression in human skin fibroblasts
- Macelignan Inhibits Melanosome Transfer Mediated by Protease-Activated Receptor-2 in Keratinocytes
- Curcumin attenuates cytochrome P450 induction in response to 2,3,7,8-tetrachlorodibenzo-p-dioxin by ROS-dependently degrading AhR and ARNT
- Protective Effects of Macelignan on Cisplatin-Induced Hepatotoxicity Is Associated with JNK Activation(Biopharmacy)
- Ginsenoside 20(S)-Protopanaxatriol (PPT) Activates Peroxisome Proliferator-Activated Receptor γ (PPARγ) in 3T3-L1 Adipocytes(Pharmacology)
- Hypoxia-Inducible Factor 1-Related Diseases and Prospective Therapeutic Tools
- Amorphous Silicon Film Deposition by Low Temperature Catalytic Chemical Vapor Deposition (
- Suppressive effect of ethanolic Kaempferia pandurata Roxb. extract on matrix metalloproteinase-2 expression in Porphyromonas gingivalis-treated human gingival fibroblasts in vitro
- Inhibitory Effect of Panduratin A on c-Jun N-Terminal Kinase and Activator Protein-1 Signaling Involved in Porphyromonas gingivalis Supernatant-Stimulated Matrix Metalloproteinase-9 Expression in Human Oral Epidermoid Cells
- Antioxidant Properties of Neohesperidin Dihydrochalcone : Inhibition of Hypochlorous Acid-Induced DNA Strand Breakage, Protein Degradation, and Cell Death(Medicinal Chemistry)
- Effects of macelignan isolated from Myristica fragrans Houtt. on UVB-induced matrix metalloproteinase-9 and cyclooxygenase-2 in HaCaT cells
- Inhibitory Effects of Macelignan Isolated from Myristica fragrans HOUTT. on Melanin Biosynthesis(Miscellaneous)
- Immunostimulating Activity of Crude Polysaccharide Extract Isolated from Curcuma xanthorrhiza Roxb
- Immunostimulating Activity of Crude Polysaccharide Extract Isolated from Curcuma xanthorrhiza Roxb.
- Effects of (+)-Catechin on the Function of Osteoblastic Cells
- meso-Dihydroguaiaretic Acid Inhibits Hepatic Lipid Accumulation by Activating AMP-Activated Protein Kinase in Human HepG2 Cells
- In Vitro Antibacterial Activity of Panduratin A against Enterococci Clinical Isolates
- Effects of Macelignan Isolated from Myristica fragrans (Nutmeg) on Expression of Matrix Metalloproteinase-1 and Type I Procollagen in UVB-Irradiated Human Skin Fibroblasts
- Activity of panduratin A isolated from Kaempferia pandurata Roxb. against multi-species oral biofilms in vitro
- Erratum: "Amorphous Silicon Film Deposition by Low Temperature Catalytic Chemical Vapor Deposition ($