Hypoxia-Inducible Factor 1-Related Diseases and Prospective Therapeutic Tools

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概要

• 論文の詳細を見る

• Hypoxia-inducible factor 1 (HIF-1) is a transcription factor that functions as a master regulator of oxygen homeostasis. HIF-1 regulates the expressions of the proteins that increase oxygen delivery, which enables cells to survive in oxygen-deficient conditions. Based on information as to which types of genes are controlled by HIF-1, it appears that HIF-1 provides pathological tissues with survival in hypoxic regions or angiogenic activity. Therefore, HIF-1 inhibitors could be useful as therapeutic agents for various diseases associated with the over-activation of HIF-1, such as cancers, cardiovascular remodeling, preeclamsia, and other angiogenesis-related diseases. In this review, we summarize the oxygen-dependent and -independent regulation of HIF-1 and introduce prospective HIF-1 inhibitors that might be useful in the treatment of HIF-1-related diseases.

• 社団法人 日本薬理学会の論文
• 2004-03-01

著者

• Kim Myung-suk

  韓国

• Kim Myung-suk

  Department Of Pharmacology Seoul National University College Of Medicine

• Park J‐w

  Pusan National Univ. Busan Kor

• PARK Jong-Wan

  Department of Physics, Chungbuk National University

• CHUN Yang-Sook

  Department of Physiology, Seoul National University College of Medicine

• Chun Yang-sook

  Department Of Physiology Seoul National University College Of Medicine

• Park Jong-wan

  Department Of Metallugical Engineering Hanyang University

• Park J‐w

  Department Of Pharmacology Seoul National University College Of Medicine

• Chun Yan-Sook

  Department of Physiology, Seoul National University College of Medicine

• Park Jong-Wan

  Department of Materials Science and Engineering, Hanyang University, 17 Haengdang-dong, Seoungdong-ku, Seoul 133-791, Korea

• Kim Myung-Suk

  Department of Biotechnology, Yonsei University

• PARK Jong-Wan

  Department of Biomedical Sciences, Seoul National University, College of Medicine

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