Inhibitory Effects of Macelignan Isolated from Myristica fragrans HOUTT. on Melanin Biosynthesis(Miscellaneous)
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概要
- 論文の詳細を見る
The aim of this study was to investigate the in vitro inhibitory effects of macelignan isolated from Myristica fragrans HOUTT. on melanogenesis and its related enzymes such as tyrosinase, tyrosinase-related protein-1 (TRP-1), and tyrosinase-related protein-2 (TRP-2) in melan-a murine melanocytes. The IC_<50> values of macelignan for melanogenesis and tyrosinase were 13 μm and 30 μM, respectively, while those of arbutin as a positive control were 990 μM and 660 μM, respectively. In Western blot analysis, macelignan also significantly decreased tyrosinase, TRP-1, and TRP-2 protein expression. These results indicate that macelignan effectively inhibits melanin biosynthesis and thus could be employed as a new skin-whitening agent.
- 公益社団法人日本薬学会の論文
- 2008-05-01
著者
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SHIM Jae-Seok
Department of Biotechnology, Yonsei University
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CHO Yumi
Department of Biotechnology, Yonsei University
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HWANG Jae-Kwan
Department of Biotechnology, Yonsei University
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Cho Yumi
Department Of Biotechnology Yonsei University
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Shim Jae-seok
Department Of Biotechnology Yonsei University
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Shim Jae-seok
Department Of Biomaterials Science And Engineering Yonsei University
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Hwang Jae-kwan
Department Of Biotechnology Yonsei University
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Hwang Jae-kwan
Department Of Biomaterials Science And Engineering Yonsei University
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Hwang Jae-kwan
Department Of Biotechnology & Bioproducts Research Center Yonsei University
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Kim Kyu-hoi
Department Of Biotechnology Yonsei University
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