Pleurospermum kamtschaticum Extract Induces Apoptosis via Mitochondrial Pathway and NAG-1 Expression in Colon Cancer Cells
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概要
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To evaluate the anticarcinogenic activity of methanol extract of Pleurospermum kamtschaticum (PKE), we assessed its apoptosis-inducing capability in HT-29 colon carcinoma cells. PKE treatment for 2 h reduced cell viability in a dose-related manner, and induced apoptotic morphological changes. Flow cytometric analysis indicated that PKE treatment at 0.05 mg/ml induced early apoptosis in 66.2% of HT-29 cells. Additionally, Bcl-2 expression was substantially reduced in PKE-treated HT-29 cells, increasing the Bax/Bcl-2 ratio. The protein levels of procaspase-9 and procaspase-3 were decreased markedly, reflecting caspase-9 and caspase-3 activation, and resulting PARP cleavage was noted in the PKE-treated HT-29 cells. Furthermore, we detected increased NAG-1 expression in the PKE-treated HT-29 cells. In an in vivo study, intraperitoneal PKE administration suppressed the formation of tumor nodules in the lungs of mice. These results indicate that PKE can serve as a beneficial supplement in the treatment and the prevention of colon cancer.
- 社団法人 日本農芸化学会の論文
- 2010-04-23
著者
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Kim Jin-Eun
Department of Oral Biology, Yonsei University College of Dentistry
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Chung Won-Yoon
Department of Oral Biology, Yonsei University College of Dentistry
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Chun Kyung-Soo
Laboratory of Molecular Carcinogenesis, National Institute of Environmental Health Sciences
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LEE Chang
Department of Oral Biology, Yonsei University College of Dentistry
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PARK Hee-Juhn
Department of Botanical Resources, Sangji University
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KIM Won-Bae
National Alpine Agricultural Experimental Station, RDA
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PARK Kwang-Kyun
Department of Oral Biology, Yonsei University College of Dentistry
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Park Kwang-kyun
Dep. Of Oral Biology Yonsei Univ. Coll. Of Dentistry
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Park Hee-juhn
Department Of Botanical Resources Sangji University
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Park Hee-juhn
Department Of Botanical Resources Sangi University
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Chung Won-yoon
Oral Cancer Res. Inst. Oral Sci. Res. Inst. And Brain Korea 21 Project Yonsei Univ. Coll. Of Dentist
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Lee Chang
Department Of Animal Science Utsunomiya University
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Chung Won-yoon
Department Of Oral Biology Yonsei University College Of Dentistry
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Chun Kyung-soo
Laboratory Of Molecular Carcinogenesis National Institute Of Environmental Health Sciences Research
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Kim Jin-eun
Department Of Oral Biology Yonsei University College Of Dentistry
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Kim Won-bae
National Alpine Agricultural Experimental Station Rda
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Park Kwang-kyun
Department Of Oral Biology And Oral Cancer Research Center College Of Dentistry Yonsei University
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Lee Chang
Department Of Oral Biology Yonsei University College Of Dentistry
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Lee Chang
Departlnent Of Biology College Of Natural Sciences Kyungpook National University Korea
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