Passive Cutaneous Anaphylaxis-Inhibitory Action of Tectorigenin, a Metabolite of Tectoridin by Intestinal Microflora(Pharmacognosy)
スポンサーリンク
概要
- 論文の詳細を見る
Tectoridin isolated from the flowers of Pueraria thunbergiana (Leguminosae) are metabolized to tectorigenin by human intestinal micro flora. When tectoridin was orally administered to rats, tectorigenin, but not tectoridin, was detected in urine after β-glucuronidase hydrolysis. The main metabolite tectorigenin potently inhibited the passive cutaneous anaphylaxis reaction and inhibited in vitro the release of β-hexosaminidase from RBL-2H3 cells induced by IgE. These results suggest that tectoridin is a prodrug, which can be transformed into the active agent tectorigenin by human intestinal bacteria and can be a candidate for antiallergic agent.
- 社団法人日本薬学会の論文
- 2004-07-01
著者
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LEE Chang
Department of Oral Biology, Yonsei University College of Dentistry
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Shin Yong
College Of Pharmacy Kyung Hee University
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Kim Dong-hyun
韓国
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Kim Dong-hyun
College Of Pharmacy Kyung Hee University
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SHIN Yong-Wook
College of Pharmacy, Kyung Hee University
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PARK Eun-Kyung
College of Pharmacy, Kyung Hee University
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Park Eun-kyung
韓国
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Park Eun-kyung
College Of Pharmacy Kyung Hee University
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Park Eun
Department Of Biochemistry Kon Kuk University
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Shin Yong-wook
College Of Pharmacy Kyung Hee University
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Choo Min-kyung
韓国
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Shin Yong‐wook
韓国
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Kim D‐h
College Of Pharmacy Kyung Hee University
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Park E‐k
College Of Pharmacy Kyung Hee University
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Lee Hae-ung
Coll. Of Pharmacy Kyung Hee Univ.
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Lee H‐u
College Of Pharmacy Kyung Hee University
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LEE Hae-Ung
College of Pharmacy, Kyung Hee University
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PARK Eun-Kyung
Department of Biochemistry, Kon Kuk University
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Han Myung
Dep. Of Food And Nutrition Kyung Hee Univ.
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Lee Chang
Department Of Animal Science Utsunomiya University
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Lee Chang
Department Of Biochemistry Kon Kuk University
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Kim D‐h
Taegu Univ. Kyungbuk Kor
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Lee Hae-ung
College Of Pharmacy Kyung Hee University
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Kim Dong-hyun
College Of Pharmacy
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Lee Chang
Departlnent Of Biology College Of Natural Sciences Kyungpook National University Korea
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