Biotransformation of Glycyrrhizin to 18β-Glycyrrhetinic Acid-3-O-β-D-glucuronide by Streptococcus LJ-22,a Human Intestinal Bacterium
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概要
- 論文の詳細を見る
By human intestinal bacteria, glycyrrhizin (18β-glycyrrhetinic acid-3-O-[β-D-glucuronopyranosyl-(1→2)-β-D-glucuronopyranoside], GL) was metabolized to 18β-glycyrrhetinic acid (GA) : the main pathway metabolized GL to GA by glucuronidases of Bacteroides J-37 and Eubacterium sp. GLH and the minor pathway metabolized GL to 18β-glycyrrhetinic acid-3-O-β-D-glucuronide (GAMG) by β-glucuronidase of Streptococcus LJ-22. β-Glucuronidase from Streptococcus LJ-22 hydrolyzed GL to GAMG (not GA). The molecular weight and optimal pH of the enzyme were 240 kDa and 5-6.
- 公益社団法人日本薬学会の論文
- 1999-03-15
著者
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Kim Dong-hyun
College Of Pharmacy Kyung Hee University
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HAN Myung
Department of Food and Nutrition, Kyung Hee University
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Han Myung
Department Of Food And Nutrition Kyung Hee University
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Lee Seung-won
College Of Pharmacy
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Kim Do-hoon
Department Of Psychiatry College Of Medicine Institute Of Natural Medicine Hallym University
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Kim D‐h
Department Of Psychiatry College Of Medicine Institute Of Natural Medicine Hallym University
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Han Myung
Department Of Food And Nutrition Kyung-hee University
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Kim Dong-hyun
College Of Pharmacy
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