Constitutive β-Gluccosidases Hydrolyzing Ginsenoside R_<b1> and R_<b2> from Human Intestinal Bacteria

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When ginsenoside R_<b1> and R_<b2> were anaerobically incubated with human intestinal microflora, these ginsenosides were metabolized to 20-O-β-D-glucopyranosyl-20(S)-protopanaxadiol (compound K) and 20(S)-protopanaxadiol. Several kinds of intestinal bacteria hydrolyzed these ginsenosides. Eubacterium sp., Strep coccus sp. and Bifidobacterium sp., which more potently hydrolyzed gentiobiose than sophorose, metabolized ginsenoside R_<b1> to compounds K via ginsenoside R_d rather than gypenoside XVII. However, Fusobacterium K-60,which more potently hydrolyzed sophorose than gentiobiose, metabolized to compound K via gypenoside XVII. Ginsenoside R_<b2> was also metabolized to compound K via ginsenoside R_d or compound O by human intestinal microflora. Eubacterium sp., Streptococcus sp. and Bifidobacterium sp. metabolized ginsenoside R_<b2> to compound K via ginsenoside R_d rather than compound O. Fusobacterium K-60 metabolized ginsenoside R_<b2> to compound K via compound O.
社団法人日本薬学会の論文
2000-12-01