Effect of Chunghyuldan in Chronic Oxazolone-Induced Mouse Dermatitis(Pharmacology)
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概要
- 論文の詳細を見る
To evaluate the antipsoriatic effect of Chunghyuldan (CHD, Daio-Orengedokuto in Japanese), which exhibited anti-inflammatory and antiischemic actions, the inhibitory activity of CHD metabolized with and without human intestinal microflora was investigated in oxazolone-induced mouse ear dermatitis. The CHD and metabolized CHD (MCHD) at concentrations of 0.1% also potently suppressed mouse ear swelling by 52.7% and 63.2% at 16d, respectively. The antipsoriatic effect between CHD and MCHD was not significantly different, although that of CHD weakly increased by the metabolism of human intestinal microflora. Both CHD and MCHD also potently reduced the mRNA levels of cyclooxygenase (COX)-2, interferon (IFN)-γ and IL-4 increased in oxazolone-applied mouse ears, but weakly inhibited that of IL-1β and TNF-α. Based on these findings, CHD may improve contact dermatitis or psoriasis by the regulation of COX-2 produced by macrophage cells and IFN-γ and IL-4 produced by Th cells.
- 社団法人日本薬学会の論文
- 2005-06-01
著者
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Shin Yong
College Of Pharmacy Kyung Hee University
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Kim Dong-hyun
College Of Pharmacy Kyung Hee University
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BAE Eun-Ah
College of Pharmacy, Kyung Hee University
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WEE Sung
College of Pharmacy, Kyung Hee University
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BAE Eun
College of Pharmacy, Kyung Hee University
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KIM Dong
College of Pharmacy, Kyung Hee University
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Kim Dong
College Of Pharmacy Kyung Hee University
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Bae Eun-ah
韓国
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Bae Eun
College Of Pharmacy Kyung Hee University
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Bae Eun-ah
College Of Pharmacy Kyung Hee University
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Shin Yong-wook
College Of Pharmacy Kyung Hee University
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Choo Min-kyung
韓国
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Shin Yong‐wook
韓国
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Wee Sung-sook
韓国
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Wee Sung
College Of Pharmacy Kyung Hee University
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Bae E‐a
College Of Pharmacy Kyung Hee University
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Bae Eun-ah
Department Of Life And Nanopharmaceutical Sciences And Department Of Pharmaceutical Science Kyung He
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Han Myung
Dep. Of Food And Nutrition Kyung Hee Univ.
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Kim D‐h
Taegu Univ. Kyungbuk Kor
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Wee Sung-Sook
College of Pharmacy, Kyung Hee University
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