Antihyperlipidemic Effect of Crocin Isolated from the Fructus of Gardenia jasminoides and Its Metabolite Crocetin(Pharmacognosy)
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概要
- 論文の詳細を見る
The pancreatic lipase inhibitors were isolated from the fructus of Gardenia jasminoides ELLIS, and their antihyperlipidemic activities were measured. Gardeniae fructus (GF) water extract inhibited pancreatic lipase activity. Crocetin and crocin were isolated from GF water extract as inhibitors of pancreatic lipase with an IC_<50> value of 2.1 and 2.6mg/ml (triolein as a substrate). Crocin and crocetin significantly inhibited the increase of serum TG level in corn oil feeding-induced triglyceridemic mice, as well as that of serum triglyceride and total and LDL cholesterol levels in Triton WR-1339-induced hyperlipidemic mice. These compounds also showed hypolipidemic activity in hyperlipidemic mice induced by high cholesterol, high fat or high carbohydrate diets for 5 weeks. The results suggest that the hypolipidemic activity of GF and its component crocin may be due to the inhibition of pancreatic lipase and crocin, and its metabolite, crocetin, can improve hyperlipidemia.
- 社団法人日本薬学会の論文
- 2005-11-01
著者
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KIM Dong
College of Pharmacy, Kyung Hee University
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Kim Dong
College Of Pharmacy Kyung Hee University
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Baek Nam-in
韓国
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Baek Namin
Graduate School Of Biotechnology And Inst. Of Life Sciences And Resources Kyunghee Univ.
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LEE In
College of Pharmacy, Kyung Hee University
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LEE Jin
Graduate School of Biotechnology and PMRC, Kyung Hee University
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BAEK Nam
Graduate School of Biotechnology and PMRC, Kyung Hee University
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Baek Nam
Graduate School Of Biotechnology & Plant Metabolism Research Center Kyung Hee University
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Lee In
College Of Pharmacy Kyung Hee University
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Lee Jin
Graduate School Of Biotechnology And Pmrc Kyung Hee University
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Lee In-Ah
College of Pharmacy, Kyung Hee University
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Baek Jin
Graduate School of Biotechnology and PMRC, Kyung Hee University
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Kim Dong-Hyun
Graduate School of Biotechnology and PMRC, Kyung Hee University
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