Inhibitory Effect of Ginsenoside Rb1 and Compound K on NO and Prostaglandin E2 Biosyntheses of RAW264.7 Cells Induced by Lipopolysaccharide(Pharmacognosy)
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概要
- 論文の詳細を見る
In this study, the antiinflammatory activities of ginsenoside Rb1, which is a main constituent of the root of Panax ginseng (Araliaceae), and of its metabolite compound K, as produced by human intestinal bacteria, on lipopolysaccharide (LPS)-induced RAW264.7 cells were investigated. Compound K potently inhibited the production of NO and prostaglandin E2 in LPS-induced RAW 264.7 cells, with IC_<50> values of 0.012 and 0.004 m_M, respectively. Compound K also reduced the expression levels of the inducible NO synthase (iNOS) and COX-2 proteins and inhibited the activation of NF-kB, a nuclear transcription factor. Compound K inhibited the NO level produced by iNOS enzyme activity in a cell-free system, but did not inhibit COX-1 and 2 activities. When ginsenoside Rb1 was orally administered to rats, compound K, but not ginsenoside Rb1, were excreted in their urine. These findings suggest that ginsenoside Rb1 can be transformed to compound K by intestinal bacteria, and compound K may be effective against inflammation.
- 社団法人日本薬学会の論文
- 2005-04-01
著者
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Shin Yong
College Of Pharmacy Kyung Hee University
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Kim Dong-hyun
韓国
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PARK Eun-Kyung
College of Pharmacy, Kyung Hee University
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KIM Dong
College of Pharmacy, Kyung Hee University
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Kim Dong
College Of Pharmacy Kyung Hee University
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Park Eun-kyung
韓国
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Park Eun-kyung
College Of Pharmacy Kyung Hee University
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Park Eun
Department Of Biochemistry Kon Kuk University
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Shin Yong-wook
College Of Pharmacy Kyung Hee University
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Park Eun
College of Pharmacy, Kyung Hee University
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Choo Min-kyung
韓国
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Shin Yong‐wook
韓国
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Kim D‐h
College Of Pharmacy Kyung Hee University
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Lee Young
Korea Food Research Institute
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Park E‐k
College Of Pharmacy Kyung Hee University
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Lee Hae-ung
Coll. Of Pharmacy Kyung Hee Univ.
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Lee H‐u
College Of Pharmacy Kyung Hee University
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LEE Hae
College of Pharmacy, Kyung Hee University
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KIM Sung
Korea Food Research Institute
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LEE Boo
Korea Food Research Institute
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Han Myung
Dep. Of Food And Nutrition Kyung Hee Univ.
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Lee Hae
College Of Pharmacy Kyung Hee University
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Kim D‐h
Taegu Univ. Kyungbuk Kor
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Kim Sung‐soo
Samsung Electronics Co. Ltd. Kor
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Lee Young
Korea Advanced Institute Of Science And Technology
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Park Eun
College Of Pharmacy Kyung Hee University
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Lee Hae-ung
College Of Pharmacy Kyung Hee University
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Park Eun
College Of Pharmacy Cbitrc College Of Pharmacy And Medical Research Center Chungbuk National Univers
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