Metabolism of 6"-O-Xylosyltectoridin and Tectoridin by Human Intestinal Bacteria and Their Hypoglycemic and in Vitro Cytotoxic Activities
スポンサーリンク
概要
- 論文の詳細を見る
6"-O-Xylosyltectoridin and tectoridin isolated from the flowers of Pueraria thunbergiana (Leguminosae), are metabolized to tectorigenin by human intestinal bacteria. Although tectoridin is metabolized to tectorigenin by most intestinal bacteria, 6"-O-xylosyltectoridin is metabolized to tectorigenin via tectoridin by only a few intestinal bacteria, such as Bifidobacterium breve K-110 and Eubacterium A-44. The metabolite, tectorigenin, had more potent hypoglycemic activity as well as in vitro cytotoxic activity against tumor cell lines than 6"-O-xylosyltectoridin and tectoridin. These results suggest that 6"-O-xylosyltectoridin and tectoridin. These results suggest that 6"-O-xylosyltectoridin and tectoridin are prodrugs which can be transformed to the active agents by human intestinal bacteria.
- 社団法人日本薬学会の論文
- 1999-12-15
著者
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LEE Kyung-Tae
College of Pharmacy, Kyung-Hee University
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Shin Yong
College Of Pharmacy Kyung Hee University
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Kim Dong-hyun
College Of Pharmacy Kyung Hee University
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BAE Eun-Ah
Department of Life and Nanopharmaceutical Sciences and Department of Pharmaceutical Science, Kyung H
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BAE Eun-Ah
College of Pharmacy, Kyung Hee University
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HAN Myung
Department of Food and Nutrition, Kyung Hee University
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CHOI Jong-Won
Department of Natural Plant Resources Science, Sang Ji University
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PARK Hee-Juhn
College of Pharmacy, Kyung Sung University
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Han Myung
Department Of Food And Nutrition Kyung Hee University
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Bae Eun-ah
韓国
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Bae Eun-ah
Department Of Food And Nutrition Kyung Hee University
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Choi Jongwon
Coll. Of Pharmacy Kyungsung Univ.
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Choi Jong-won
韓国
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Choi Jong-won
College Of Pharmacy Kyung-sung University
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Lee Kyung-tae
韓国
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Lee Kyung-tae
College Of Pharmacy Kyung-hee University
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Lee Kyung-tae
Coll. Of Pharmacy Kyung-hee Univerisity
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Park Hee-juhn
Department Of Pharmaceutical Engineering Sangji University
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Park Hee-juhn
韓国
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Park Hee-juhn
Division Of Applied Plant Sciences Sangji University
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Park Hee-juhn
Department Of Botanical Resources Sangi University
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Kim Deog
College Of Pharmacy Kyung Hee University
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Lee Kyung
College Of Pharmacy Kyung Hee University
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Lee Kyung-won
韓国
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Choo Min-kyung
College Of Pharmacy Kyung Hee University
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Choo Min-kyung
韓国
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Shin Yong‐wook
韓国
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Kim D‐h
College Of Pharmacy Kyung Hee University
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Bae E‐a
College Of Pharmacy Kyung Hee University
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Choi Jong-won
Coll. Of Pharmacy Kyungsung Univ.
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Choi Jung-hye
Department Of Internal Medicine Hanyang University
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Park Hee-joun
Department Of Botanical Resources Sangji University
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Bae Eun-ah
Department Of Life And Nanopharmaceutical Sciences And Department Of Pharmaceutical Science Kyung He
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Han Myung
Dep. Of Food And Nutrition Kyung Hee Univ.
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Kim D‐h
Taegu Univ. Kyungbuk Kor
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Choi Jung-hye
Dep. Of Oriental Pharmaceutical Sci. Coll. Of Pharmacy Kyung Hee Univ.
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Choi Jeongeun
College Of Pharmacy Kyungsung University
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Kim Dong-hyun
College Of Pharmacy
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