A Cytotoxic and Apoptosis-Inducing Sesquiterpenoid Isolated from the Aerial Parts of Artemisia princeps PAMPANINI (Sajabalssuk)
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概要
- 論文の詳細を見る
Repeated silica gel and octadecyl silica gel (ODS) column chromatography of the aerial parts of Artemisia princeps PAMPANINI (Sajabalssuk) led to the isolation of a new Sesquiterpenoid, 3-((S)-2-methylbutyryloxy)-costu-1(10),4(5)-dien-12,6α-olide (2), along with two previously reported sesquiterpenoids: 8α-angeloyloxy-3β,4β-epoxy-6βH,7αH,8βH-guaia-1(10),11(13)-dien-12,6α-olide (1, carlaolide B) and 3β,4β-epoxy-8α-isobutyryloxy-6βH,7αH,8βH-guaia-1(10),11(13)-dien-12,6α-olide (3, carlaolide A). The structure of compound 2 was elucidated by spectroscopic data analysis, including one dimensional (1D) and two dimensional (2D) nuclear magnetic resonance (NMR) experiments. Of the isolates, compound 2 exhibited potent cytotoxicity against human cervix adenocarcinoma cells and induced apoptosis.
- 社団法人日本薬学会の論文
- 2008-08-01
著者
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Lee Kyung-tae
Coll. Of Pharmacy Kyung-hee Univerisity
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Lee Kyung-tae
Department Of Life And Nanopharmaceutical Sciences College Of Pharmacy Kyung Hee University
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Lee Kyung-tae
Coll. Of Medical Sci. Kyung Hee Univ.
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Lee Kyung-tae
Department Of Biochemistry College Of Pharmacy Kyung Hee University
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Back Nam-in
The Graduate School Of Biotechnology & Plant Metabolism Research Center Kyung Hee University
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BANG Myun-Ho
The Skin Biotechnology Center, Kyung Hee University
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HAN Min-Woo
The Graduate School of Biotechnology & Plant Metabolism Research Center, Kyung Hee University
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SONG Myoung-Chong
The Graduate School of Biotechnology & Plant Metabolism Research Center, Kyung Hee University
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CHO Jin-Gyeong
The Graduate School of Biotechnology & Plant Metabolism Research Center, Kyung Hee University
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CHUNG Hae-Gon
Ganghwa Agricultural R&D Center
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JEONG Tae-Sook
National Research Laboratory of Lipid Metabolism & Atherosclerosis, Korea Research Institute of Bios
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CHOI Myung-Sook
Department of Food Science and Nutrition, Kyungpook National University
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KIM Se-Young
The Graduate School of Biotechnology & Plant Metabolism Research Center, Kyung Hee University
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BAEK Nam-In
The Graduate School of Biotechnology & Plant Metabolism Research Center, Kyung Hee University
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Han Min-woo
The Graduate School Of Biotechnology & Plant Metabolism Research Center Kyung Hee University
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Bang Myun-ho
The Skin Biotechnology Center Kyung Hee University
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Kim Se-young
The Graduate School Of Biotechnology & Plant Metabolism Research Center Kyung Hee University
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Cho Jin-gyeong
The Graduate School Of Biotechnology & Plant Metabolism Research Center Kyung Hee University
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Jeong Tae-sook
National Research Laboratory Of Lipid Metabolism & Atherosclerosis:molecular Science University
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Song Myoung-chong
The Graduate School Of Biotechnology & Plant Metabolism Research Center Kyung Hee University
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Chung Hae-gon
Ganghwa Agricultural R&d Center
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Choi Myung-sook
Department Of Food Science And Nutrition Kyungpook National University
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Jeong Tae-sook
National Research Laboratory Of Lipid Metabolism & Atherosclerosis Korea Research Institute Of B
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