Human ACAT-1 and ACAT-2 Inhibitory Activities of Pentacyclic Triterpenes from the Leaves of Lycopus lucidus TURCZ.(Pharmacognosy)
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概要
- 論文の詳細を見る
Acyl-CoA: cholesterol acyltransferase (ACAT) catalyzes the acylation of cholesterol to cholesteryl ester with long chain fatty acids and ACAT inhibition is a useful strategy for treating hypercholesterolemia or atherosclerosis. Pentacyclic triterpenes, ursolic acid (1), oleanolic acid (2), and betulinic acid (3) were isolated from the methanol extracts of the leaves of Lycopus lucidus TURCZ. by bioassay-guided fractionation. The structures of compounds 1-3 were elucidated by their spectroscopic data analysis. Among them, betulinic acid (3) exhibited more potent human ACAT-1 and ACAT-2 inhibitory activities with IC_<50> values of 16.2±0.6 and 28.8±1.3μM, respectively.
- 公益社団法人日本薬学会の論文
- 2006-02-01
著者
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JEONG Tae-Sook
National Research Laboratory of Lipid Metabolism & Atherosclerosis, Korea Research Institute of Bios
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Jeong Tae-sook
National Research Laboratory Of Lipid Metabolism & Atherosclerosis:molecular Science University
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Park Yong-dae
National Research Laboratory Of Lipid Metabolism & Atherosclerosis:molecular Science University
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Lee Woo
National Research Laboratory Of Lipid Metabolism & Atherosclerosis:molecular Science University
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Lee Woo
National Institute Of Toxicological Research Korea Fda
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IM Kyung-Ran
National Research Laboratory of Lipid Metabolism & Atherosclerosis, Korea Research Institute of Bios
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SUNG Nack-Do
College of Agriculture, Chungnam National University
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Sung Nack-do
College Of Agriculture Chungnam National University
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Jeong Tae-sook
National Research Laboratory Of Lipid Metabolism & Atherosclerosis Korea Research Institute Of B
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Im Kyung-ran
National Research Laboratory Of Lipid Metabolism & Atherosclerosis Korea Research Institute Of B
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Lee Woo
Eco Friendly Biomaterial Research Center Korea Research Institute Of Bioscience And Biotechnology
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Im Kyung-Ram
National Research Laboratory of Lipid Metabolism & Atherosclerosis, Korea Research Institute of Bioscience and Biotechnology:College of Agriculture, Chungnam National University
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