Antioxidant Effects of Quinoline Alkaloids and 2,4-Di-tert-butylphenol Isolated from Scolopendra subspinipes(Pharmacognosy)
スポンサーリンク
概要
- 論文の詳細を見る
The oxidized low-density lipoprotein (ox-LDL) plays a critical role at the early stages of atherosclerosis. Thus, the prevention of LDL-oxidation by antioxidants may arrest the progression of atherosclerosis. Two quinoline alkaloids, 3, 8-dihydroxyquinoline (1) and 2, 8-dihydroxy-3, 4-dimethoxyquinoline (3), and 2, 4-di-tertbutylphenol (2) were isolated from the dried body of Scolopendra subspinipes. Compounds 1-3 exhibited antioxidant activities on copper-mediated (1:IC_<50>=2.6μM, 2:IC_<50>=8.2μM, 3:IC_<50>=63.0μM), AAPH-mediated oxidation (1:IC_<50>=3.9μM, 2:IC_<50>=9.9μM, 3:IC_<50>=71.8μM), and SIN-1-mediated oxidation (1:70%, 2:52%, 3:29% at 5.0μM) in the TEARS assay. The antioxidant activities of compounds 1-3 were tested with respect to other parameters, such as the lag time of conjugated diene fromation, relative electrophoretic mobility (REM) of ox-LDL, and apoB-100 fragmentation on copper-mediated LDL-oxidation. In addition, compounds 1-3 showed 1, 1-diphenyl-2-picrylhydrasyl (DPPH) radical scavenging activity and compound 1 also exhibited metal chelating activity.
- 2006-04-01
著者
-
JEONG Tae-Sook
National Research Laboratory of Lipid Metabolism & Atherosclerosis, Korea Research Institute of Bios
-
Jeong Tae-sook
National Research Laboratory Of Lipid Metabolism & Atherosclerosis Korea Research Institute Of B
-
Lee Woo
National Research Laboratory Of Lipid Metabolism & Atherosclerosis:molecular Science University
-
Oh Hyun-woo
Insect Resources Laboratory Korea Research Institute Of Bioscience And Biotechnology
-
Xu Ming-zhe
Insect Resources Laboratory Korea Research Institute Of Bioscience And Biotechnology
-
Lee Woo
National Institute Of Toxicological Research Korea Fda
-
Song Kyoung-bin
Department Of Food Science & Technology Chungnam National University
-
Park Doo-sang
Insect Resources Laboratory Korea Research Institute Of Bioscience And Biotechnology
-
YOON Mi-Ae
Insect Resources Laboratory, Korea Research Institute of Bioscience and Biotechnology
-
PARK Ho-Yong
Insect Resources Laboratory, Korea Research Institute of Bioscience and Biotechnology
-
Park Ho-yong
Insect Resources Laboratory Korea Research Institute Of Bioscience And Biotechnology
-
Yoon Mi-ae
Insect Resources Laboratory Korea Research Institute Of Bioscience And Biotechnology:department Of F
-
Lee Woo
National Research Laboratory Of Lipid Metabolism & Atherosclerosis Korea Research Institute Of B
関連論文
- A Cytotoxic and Apoptosis-Inducing Sesquiterpenoid Isolated from the Aerial Parts of Artemisia princeps PAMPANINI (Sajabalssuk)
- Protective Effect of the Ethanol Extract of the Roots of Brassica rapa on Cisplatin-Induced Nephrotoxicity in LLC-PK_1 Cells and Rats(Pharmacognosy)
- Lavandulyl Flavonoids from Sophora flavescens Suppress Lipopolysaccharide-Induced Activation of Nuclear Factor-κB and Mitogen-Activated Protein Kinases in RAW264.7 Cells
- Low Density Lipoprotein (LDL)-Antioxidant Flavonoids from Roots of Sophora flavescens(Pharmacognosy)
- Antioxidant Effects of Quinoline Alkaloids and 2,4-Di-tert-butylphenol Isolated from Scolopendra subspinipes(Pharmacognosy)
- P-115 Comet and micronucleus assay in rat liver tissue for the early screening of genotoxic hepatocarcinogen(Poster Session)
- P-011 Study on the mutagenic mode of action by toxicogenomics approach(Poster Session)
- Human Acyl-CoA : Cholesterol Acyltransferase Inhibitory Activities of Aliphatic Acid Amides from Zanthoxylum piperitum DC.(Pharmacognosy)
- Human ACAT-1 and ACAT-2 Inhibitory Activities of Pentacyclic Triterpenes from the Leaves of Lycopus lucidus TURCZ.(Pharmacognosy)
- Manassantin A and B From Saururus chinensis Inhibit Interleukin-6-Induced Signal Transducer and Activator of Transcription 3 Activation in Hep3B Cells
- Norkurarinol Inhibits Toll-Like Receptor 3 (TLR3)-Mediated Pro-inflammatory Signaling Pathway and Rotavirus Replication