Low Density Lipoprotein (LDL)-Antioxidant Flavonoids from Roots of Sophora flavescens(Pharmacognosy)
スポンサーリンク
概要
- 論文の詳細を見る
Oxidation of low density lipoprotein (LDL) is strongly implicated as a key process in the onset of atherosclerosis. In this study, nine alkylated(C_10-C_5) flavonoids from Sophora flavescens were examined for their inhibitory effects on copper-induced LDL oxidation. Of the flavonoids tested, sophoraflavanone G(1), kurarinone (2), kurarinol (3), norkurarinol (4), and kuraridin (9) inhibited the generation of thiobarbituric acid reactive substances (TBARS) with IC_<50>s of 7.9,14.5,22.0,26.9, and 17.5μM, respectively. The most potent inhibitor, compound 1, also demonstrated significant activities in complementary in vitro investigations, such as lag time (130min at 5μM), relative electrophoretic mobility (REM) of ox-LDL (80% inhibition at 20μM), and fragmentation of apoB-100 (inhibition of 71%at 20μM). Analysis of the structures of these compounds reveals that a resorcinol moiety in the B-ring is strongly correlated with protection of LDL-oxidation.
- 公益社団法人日本薬学会の論文
- 2008-11-01
著者
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JEONG Tae-Sook
National Research Laboratory of Lipid Metabolism & Atherosclerosis, Korea Research Institute of Bios
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LEE Jin
Division of Reproductive Endocrinology and Infertility, Department of Obstetrics and Gynecology, Col
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Lee Jin
Division Of Biotech. Faculty Of Life. Res. Dong-a Univ.
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PARK Ki
Division of Plant Environment, National Yeongnam Agricultural Experiment Station, RDA
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Kim Hoi
Division of Applied Life Science, Gyeongsang National University
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Lee Woo
Bioindustry Research Center, Korea Research Institute of Bioscience and Biotechnology
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Lee Woo
National Research Laboratory Of Lipid Metabolism & Atherosclerosis:molecular Science University
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Lee Woo
Bioindustry Research Center Kribb
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RYU Young
Division of Nuclear Medicine, Department of Diagnostic Radiology, Gangnam Severance Hospital, Resear
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AN So
National Research Laboratory of Lipid Metabolism & Atherosclerosis, Korea Research Institute of Bios
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An So
National Research Laboratory Of Lipid Metabolism & Atherosclerosis Korea Research Institute Of B
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Kim Hoi
Division Of Applied Life Science (bk21 Program) Eb-ncrc Institute Of Agriculture & Life Science
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Ryu Young
Division Of Applied Life Science (bk21 Program) Eb-ncrc Institute Of Agriculture & Life Science
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Ryu Young
Division Of Applied Life Science (bk21 Program) Institute Of Agricultural & Life Sciences Depart
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Park Ki
Division Of Applied Life Science (bk21 Program) Eb-ncrc Institute Of Agriculture & Life Science
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Jeong Tae-sook
National Research Laboratory Of Lipid Metabolism & Atherosclerosis Korea Research Institute Of B
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Park Ki
Division Of Applied Life Science (bk21 Program) Institute Of Agricultural & Life Sciences Depart
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Lee Woo
Eco Friendly Biomaterial Research Center Korea Research Institute Of Bioscience And Biotechnology
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Lee Jin
Division Of Applied Life Science (bk21 Program) Department Of Agricultural Chemistry Institute Of Ag
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Park Ki
Division Of Applied Life Science (bk21 Program Ials) Gyeongsang National University
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Lee Jin
Division Of Applied Life Science (bk21 Program) Eb-ncrc Institute Of Agriculture & Life Science Gyeongsang National University
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