Lavandulyl Flavonoids from Sophora flavescens Suppress Lipopolysaccharide-Induced Activation of Nuclear Factor-κB and Mitogen-Activated Protein Kinases in RAW264.7 Cells
スポンサーリンク
概要
- 論文の詳細を見る
Oxidized low-density lipoprotein (oxLDL) and reactive oxygen species (ROS) play key roles in the early stage of atherosclerosis. Nitric oxide (NO) and ROS are responsible for regulation of the transcriptional pathways of nuclear Factor-κB (NF-κB) and mitogen-activated protein kinase (MAPK), key regulators of cellular inflammatory and immune responses. Previously, we examined LDL-antioxidant activities of the nine flavonoids isolated from Sophora flavescens. Among these, two lavandulyl flavonoids, kurarinone (1) and kuraridin (2) inhibited inducible nitric oxide synthase (iNOS)-dependent NO production and ROS generation, and suppressed remarkably the expression of inflammatory cytokines, CCL2, tumor necrosis factor (TNF)-α, interleukin (IL)-1β, and iNOS in lipopolysaccharide (LPS)-stimulated RAW264.7 macrophages. Moreover, compounds 1 and 2 attenuated NF-κB activation by inhibition of IκBα proteolysis and p65 nuclear translocation, as well as phosphorylation of extracellular signal-regulated kinase (ERK)1/2, c-Jun N-terminal kinase (JNK), and p38 MAP kinases.
- 日本薬学会の論文
著者
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JEONG Tae-Sook
National Research Laboratory of Lipid Metabolism & Atherosclerosis, Korea Research Institute of Bios
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PARK Ki
Division of Plant Environment, National Yeongnam Agricultural Experiment Station, RDA
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Park Ki
Division Of Biological Sciences Pusan National University
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Han Jong-Min
National Research Laboratory of Lipid Metabolism & Atherosclerosis, Korea Research Institute of Bios
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Jin Yue-Yan
National Research Laboratory of Lipid Metabolism & Atherosclerosis, Korea Research Institute of Bios
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Kim Hoi
Division of Applied Life Science, Gyeongsang National University
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Lee Woo
Bioindustry Research Center, Korea Research Institute of Bioscience and Biotechnology
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Lee Woo
Bioindustry Research Center Kribb
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Kim Hoi
Division Of Applied Life Science (bk21 Program) Eb-ncrc Institute Of Agriculture & Life Science
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Park Ki
Division Of Applied Life Science (bk21 Program) Eb-ncrc Institute Of Agriculture & Life Science
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Park Ki
Division Of Applied Life Science (bk21 Program Ials) Gyeongsang National University
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JEONG Tae-Sook
National Research Laboratory of Lipid Metabolism & Atherosclerosis, Korea Research Institute of Bioscience and Biotechnology
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Park Ki
Division of Applied Life Science, Gyeongsang National University
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Han Jong-Min
National Research Laboratory of Lipid Metabolism & Atherosclerosis, Korea Research Institute of Bioscience and Biotechnology
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Jin Yue-Yan
National Research Laboratory of Lipid Metabolism & Atherosclerosis, Korea Research Institute of Bioscience and Biotechnology
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