Protective Effect of the Ethanol Extract of the Roots of Brassica rapa on Cisplatin-Induced Nephrotoxicity in LLC-PK_1 Cells and Rats(Pharmacognosy)

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概要

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• A study was conducted to determine whether the ethanol extract of the roots of Brassica rapa (EBR) ameliorates cisplatin-induced nephrotoxicity in terms of oxidative stress, as characterized by lipid peroxidation, reactive oxygen species (ROS) production, and glutathione (GSH) depletion in LLC-PK_1 cells. Pretreatment of cells with EBR prevented cisplatin-induced decreases in cell viability and cellular GSH content. The effect of EBR was then investigated in rats given EBR for 14 d before cisplatin administration. A single dose of cisplatin (7mg/kg, i.p.) caused kidney damage manifested by an elevation in blood urea nitrogen (BUN), serum creatinine, and urine lactate dehydrogenase (LDH) levels. Also, renal tissue from cisplatin-treated rats showed a significant increase in malondialdehyde (MDA) production, and in the activities of aldehyde oxidase (AO) and xanthine oxidase (XO). Moreover, a significant decrease in the activities of antioxidant enzymes, such as, glutathione peroxidase (GPx), superoxide dismutase (SOD) and catalase (CAT) was observed in cisplatin-treated rats versus salinetreated normal group. In contrast, rats given EBR showed lower blood levels of BUN and creatinine, and of urinary LDH. Moreover, EBR prevented the rise of MDA production and the induction of AO and XO activities. This extract also recovered the reduced activities of GPx, SOD and CAT. Taken together, our data indicate that the ethanol extract of the roots of Brassica rapa (EBR) has a protective effect against cisplatin-induced nephrotoxicity because it attenuates oxidative stress.

• 社団法人日本薬学会の論文
• 2006-12-01

著者

• Lee Kyung-tae

  Coll. Of Pharmacy Kyung-hee Univerisity

• Lee Kyung-tae

  Department Of Life And Nanopharmaceutical Sciences College Of Pharmacy Kyung Hee University

• Lee Kyung-tae

  Coll. Of Medical Sci. Kyung Hee Univ.

• Lee Kyung-tae

  Department Of Biochemistry College Of Pharmacy Kyung Hee University

• Back Nam-in

  The Graduate School Of Biotechnology & Plant Metabolism Research Center Kyung Hee University

• CHUNG Hae-Gon

  Ganghwa Agricultural R&D Center

• JEONG Tae-Sook

  National Research Laboratory of Lipid Metabolism & Atherosclerosis, Korea Research Institute of Bios

• CHOI Myung-Sook

  Department of Food Science and Nutrition, Kyungpook National University

• KIM Yang-Hee

  Department of Pharmaceutical Biochemistry, College of Pharmacy, Kyung-Hee University

• KIM Yong-Won

  Department of Pharmaceutical Biochemistry, College of Pharmacy, Kyung-Hee University

• OH Young-Jun

  Graduate School of Biotechnology & Plant Metabolism Research Center, Kyung-Hee University

• BACK Nam-In

  Graduate School of Biotechnology & Plant Metabolism Research Center, Kyung-Hee University

• CHUNG Sun-A

  GangHwa Agricultural R&D Center

• Jeong Tae-sook

  National Research Laboratory Of Lipid Metabolism & Atherosclerosis:molecular Science University

• Kim Yong-won

  Department Of Oriental Pharmaceutical Science And Kyung Hee East-west Pharmaceutical Research Instit

• Chung Sun-a

  Ganghwa Agricultural R&d Center

• Oh Young-jun

  Graduate School Of Biotechnology & Plant Metabolism Research Center Kyung-hee University

• Chung Hae-gon

  Ganghwa Agricultural R&d Center

• Choi Myung-sook

  Department Of Food Science And Nutrition Kyungpook National University

• Kim Yang-hee

  Department Of Pharmaceutical Biochemistry College Of Pharmacy Kyung-hee University

• Jeong Tae-sook

  National Research Laboratory Of Lipid Metabolism & Atherosclerosis Korea Research Institute Of B

• Kim Yang-Hee

  Department of Pharmaceutical Biochemistry and Department of Life and Nanopharmaceutical Science, Kyung Hee University

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