The Ameliorative Effect of 23-Hydroxytormentic Acid Isolated from Rubus coreanus on Cisplatin-Induced Nephrotoxicity in Rats

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概要

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• Previously, the authors demonstrated that the triterpenoid glycoside niga-ichigoside F1 (NIF1) and its aglycone 23-hydroxytormentic acid (23-HTA) isolated from the unripe fruits of Rubus coreanus (Rosaceae) ameliorate cisplatin-induced toxicity in renal epithelial LLC-PK1 cells. In the present study, the nephroprotective effects of NIF1 and 23-HTA were investigated in Sprague-Dawley rats with acute renal injury induced by a single intraperitoneal (i.p.) injection of cisplatin (7 mg/kg). Pretreatment with 23-HTA (10 mg/kg/d, per os (p.o.)) significantly reduced cisplatin-induced elevations in blood urea nitrogen (BUN) and serum creatinine level, whereas NIF1 (10 mg/kg, p.o.) slightly reduced these levels. In addition, pretreatment with 23-HTA prevented cisplatin-induced hydroxyl radical generation, malondialdehyde (MDA) production, glutathione (GSH) depletion, and cisplatin-induced changes in the activities of oxidant and antioxidant enzymes in rat renal tissues. In addition, histopathological examinations showed that 23-HTA pretreatment reduced cisplatin-induced acute tubular necrosis and histological changes. In contrast, NIF1 was found to have a slight or no influence on cisplatin-induced oxidative enzymes and acute tubular necrosis. Taken together, these results suggest that protective effect of 23-HTA pretreatment on cisplatin-induced renal damage is associated with the attenuation of oxidative stress and the preservation of antioxidant enzymes.

著者

• Rim Hong-Kun

  Department of Pharmacology, College of Oriental Medicine, Institute of Oriental Medicine, Kyung Hee

• Choi Jong-won

  College Of Pharmacy Kyung-sung University

• Lee Kyung-tae

  Department Of Biochemistry College Of Pharmacy Kyung Hee University

• Park Hee-juhn

  Department Of Botanical Resources Sangi University

• Choi Jung-hye

  Department Of Internal Medicine Hanyang University

• Kim Yang-hee

  Department Of Pharmaceutical Biochemistry College Of Pharmacy Kyung-hee University

• Park Jae-Hoon

  Medical Science and Engineering Research Center for Bioreaction to Reactive Oxygen Species, School o

• Kim Soo-Dong

  Department of Urology, College of Medicine, Dong-A University

• Jeong Seo-Young

  Department of Life and Nanopharmaceutical Science, College of Pharmacy, Kyung Hee University

• Sohn Se-Il

  Department of Pharmaceutical Biochemistry, College of Pharmacy, Kyung Hee University

• Rim Hong-Kun

  Department of Pharmaceutical Biochemistry, College of Pharmacy, Kyung Hee University

• Rim Hong-Kun

  Department of Pharmaceutical Biochemistry and Department of Life and Nanopharmaceutical Science, Kyung Hee University

• Kim Yang-Hee

  Department of Pharmaceutical Biochemistry and Department of Life and Nanopharmaceutical Science, Kyung Hee University

• Lee Kyung-Tae

  Department of Pharmaceutical Biochemistry, College of Pharmacy, Kyung Hee University

• Choi Jung-Hye

  Department of Life and Nanopharmaceutical Science, College of Pharmacy, Kyung Hee University

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