Cell Growth of Ovarian Cancer Cells is Stimulated by Xenoestrogens through an Estrogen-Dependent Pathway, but Their Stimulation of Cell Growth Appears not to be Involved in the Activation of the Mitogen-Activated Protein Kinases ERK-1 and p38

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概要

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• Although endocrine disrupting chemicals (EDCs) may interfere with the endocrine system(s) of our body and have estrogenicity or androgenicity, the exact mechanism(s) underlying their detrimental effects is not clearly understood. Thus, in this study, we evaluated the effects of EDCs on proliferation and regulation of transcription of estrogen receptor (ER)-positive BG-1 ovarian cancer cells, and their possible mechanisms were further examined. Treatment with bisphenol A (BPA), nonylphenol (NP), octylphenol (OP) and methoxychlor (MXC) for 24 h resulted in an increase of cell proliferation. Treatment with BPA, NP, OP and MXC increased the estrogen response element (ERE) activity. The increase of cell proliferation and activation of ERE were reversed in the presence of an estrogen receptor antagonist, ICI 182780. These results suggest that ER is involved in EDC-mediated pathway in ovarian cancer cells. Based on this, we further investigated the involvement of EDCs in activation of mitogen-activated protein kinase (MAPK) in relation to cell growth. BPA rapidly induced activation of extracellular signal-regulated kinase (ERK) 1/2 and p38 MAPK at 15 min, but the effect of BPA (10 μM) on stimulation of cell growth was not blocked by pretreatment with inhibitors of ERK1/2 (PD98059) or p38 (SB203580) in a dose-dependent manner. Taken together, EDC-induced proliferation is mediated by a genomic effect through ERs and ERE, but EDC-activated MAPK is unlikely to be involved in EDC-induced cell growth in estrogen-responsive ovarian cancer cells.

• 日本繁殖生物学会の論文
• 2009-02-01

著者

• JEUNG Eui-Bae

  Laboratory of Veterinary Biochemistry and Molecular Biology, College of Veterinary Medicine, Chungbu

• Kim Ki-yon

  Department Of Obstetrics And Gynecology British Columbia Women's Hospital Child And Family Rese

• Kim Ki-yon

  Depariments Of The Riogenology Seoul National University

• Choi Kyung-chul

  韓国

• Choi Kyung-chul

  Department Of Obstetrics And Gynecology British Columbia Women's Hospital Child And Family Rese

• Choi Kyung-chul

  Laboratory Of Veterinary Biochemistry And Molecular Biology College Of Veterinary Medicine Chungbuk

• Choi Kyung-chul

  Laboratory Of Veterinary Biochemistry And Immunology College Of Veterinary Medicine Chungbuk Nationa

• Leung Peter

  Department Of Obstetrics And Gynecology Child And Family Research Institute University Of British Co

• Choi Jung-hye

  Department Of Internal Medicine Hanyang University

• Choi Jung-hye

  Department Of Obstetrics And Gynecology British Columbia Women's Hospital Child And Family Rese

• Jung Eui-man

  Laboratory Of Veterinary Biochemistry And Molecular Biology College Of Veterinary Medicine Chungbuk

• Jeung Eui-bae

  カナダ

• Jeung E‐b

  Chungbuk National Univ. Chungbuk Kor

• Jeung Eui-bae

  Laboratory Of Veterinary Biochemistry And Immunology College Of Veterinary Medicine Chungbuk Nationa

• PARK Se-Hyung

  Department of Obstetrics and Gynecology, British Columbia Women's Hospital, Child and Family Researc

• AN Beum-Soo

  Department of Obstetrics and Gynecology, British Columbia Women's Hospital, Child and Family Researc

• An Beum-soo

  Department Of Obstetrics And Gynecology British Columbia Women's Hospital Child And Family Rese

• Park Se-hyung

  Department Of Obstetrics And Gynecology British Columbia Women's Hospital Child And Family Rese

• Choi Kyung-chul

  Department Of Neurosurgery Wooridul Spine Hospital

• Leung Peter

  Department Of Obstetrics And Gynaecology University Of British Columbia

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