耳由来線維芽細胞から再構築された胚に由来するフリーマーチンの発生 (短報)
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概要
- 論文の詳細を見る
人工授精 (AI) と胚移植 (ET) 両法の組み合わせは牛のクローン作出時の過大子症候群の発生防止に効果的であるが, フリーマーチンの発生を引き起こす可能性がある. 本研究では51個の再構築胚を前もってAIされた受卵牛に移植した. 9頭の双子妊娠のうち, 3頭が雄と雌の双子を出産した. 雌は粗剛で長い陰毛を有し, 膣は短く盲管となっていた. 剖検によって, 精索を介して子宮に付着する未発達の精巣と精巣上体がみられ, 精嚢も認められた. すべての雌で性染色体キメラ (60, XX/60, XY) を示した. 今回の結果から, AIとETの組み合わせによってフリーマーチンが生じること, それが牛のクローン作出時の影響を減じることが示唆された.
- 社団法人日本獣医学会の論文
- 2001-05-25
著者
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Kim Ki-yon
Department Of Obstetrics And Gynecology British Columbia Women's Hospital Child And Family Rese
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Kim Ki-yon
Depariments Of The Riogenology Seoul National University
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Kim Ki-yon
Departments Of Theriogenology Seoul National University
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HWANG Woo-Suk
Depariments of The riogenology Seoul National University
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CHO Jong-Ki
Depariments of The riogenology Seoul National University
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SHIN Soo-Jung
Depariments of The riogenology Seoul National University
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KIM Sung-Ki
Depariments of The riogenology Seoul National University
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PARK Jong-Im
Depariments of The riogenology Seoul National University
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KIM Dae-Yong
Pathology, College of Veterinary Medicine, Seoul National University
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LEE Jung-Keun
Pathology, College of Veterinary Medicine, Seoul National University
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LIM Jeong
Department of Gamete Biotechnology, College of Agricultural Biotechnology, Seoul National University
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LEE Bycong-Chun
Depariments of The riogenology Seoul National University
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Shin S‐j
Depariments Of The Riogenology Seoul National University
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Lim Jeong
Department Of Agricultural Biotechnology Seoul National University
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Lim Jeong
Department Of Gamete Biotechnology College Of Agricultural Biotechnology Seoul National University
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Kim Dae-yong
Pathology College Of Veterinary Medicine Seoul National University
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Lee Jung-keun
Pathology College Of Veterinary Medicine Seoul National University
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Cho J‐k
Seoul National Univ. Seoul Kor
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