Tectorigenin, an Isoflavone of Pueraria thunbergiana BENTH., Induces Differentiation and Apoptosis in Human Promyelocytic Leukemia HL-60 Cells
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概要
- 論文の詳細を見る
Cytotoxic effrects of six isoflavonoids, tectorigenin, glycitein, tectoridin, glycitin, 6"-O-xylosyltectoridin, and 6"-O-xylosylglycitin isolated from the flower of Pueraria thunbergiana BENTH. together with genistein, a known differentiation and apoptosis inducer, were examined. Among these isoflavonoids, tectorigenin and genistein exhibited cytotoxicity against various human cancer cells; glycitein showed only mild cytotoxicity. These results suggest that the isoflavone structure and 5-hydroxyl group are crucial for the cytotoxic properties and that glycosides are inactive. Moreover, tectorigenin induced differentiation of human promyelocytic leukemia HL-60 cells to granulocytes and monocytes/macrophages, and caused apoptotic changes of DNA in the cells, as did genistein. Tectorigenin also inhibited autophosphorylation of epidermal growth factor(EGF)receptor by EGF and decreased the expression of Bcl-2 protein, with less activity than genistein. From these results, tectorigenin may be a possible therapeutic agent for leukemia.
- 社団法人日本薬学会の論文
- 2001-10-01
著者
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CHOI Jung-Hye
College of Pharmacy, Kyung-Hee University
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PARK Hee-Juhn
Division of Applied Plant Sciences, Sang-Ji University
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LEE Kyung-Tae
College of Pharmacy, Kyung-Hee University
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MIYAMOTO Ken-ichi
Department of Pharmacology and Pharmaceutics, Graduate School of Natural Science and Technology, Kan
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CHOI Jong-Won
College of Pharmacy, Kyung-Sung University
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Choi Jongwon
Coll. Of Pharmacy Kyungsung Univ.
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Choi Jong-won
韓国
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Choi Jong-won
College Of Pharmacy Kyung-sung University
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Kim You-ah
Div. Of Marine Environment & Bioscience Korea Maritime Univ.
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Lee Kyung-tae
韓国
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Lee Kyung-tae
College Of Pharmacy Kyung-hee University
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Lee Kyung-tae
Coll. Of Pharmacy Kyung-hee Univerisity
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Lee Kyung-tae
Coll. Of Medical Sci. Kyung Hee Univ.
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Park Hee-juhn
Department Of Pharmaceutical Engineering Sangji University
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Park Hee-juhn
韓国
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Park Hee-juhn
Division Of Applied Plant Sciences Sangji University
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Park Hee-juhn
Department Of Botanical Resources Sangi University
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KIM Young-Kwan
College of Pharmacy, Kyung-Hee University
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SOHN ll-Cheol
College of Pharmacy, Kyung Hee University
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ITOH Yoshie
Department of Hospital Pharmacy, School of Medicine, Kanazawa University
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Lee Kyung
College Of Pharmacy Kyung Hee University
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Lee Kyung-won
韓国
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Lee Kyung‐won
Kyung Hee Univ. Seoul Kor
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Kim Yun-kyung
Department Of Oriental Pharmacy College Of Pharmacy Wonkwang University
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Sohn Il-cheol
College Of Pharmacy Kyung Hee University
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Kim You-ah
韓国
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Kim Y‐k
Wonkwang Univ. Jeonbuk Kor
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Choi Jong-won
Coll. Of Pharmacy Kyungsung Univ.
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Choi Jung-hye
Department Of Internal Medicine Hanyang University
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Park Hee-joun
Department Of Botanical Resources Sangji University
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Miyamoto Ken-ichi
Department Of Hospital Pharmacy School Of Medicine Kanazawa University
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Miyaamoto Ken-ichi
Department Of Medical Informatics Graduate School Of Medical Science Kanazawa University
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Miyamoto Ken-ichi
Graduate School Of Natural Science And Technology Kanazawa University
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Choi Jung-hye
Dep. Of Oriental Pharmaceutical Sci. Coll. Of Pharmacy Kyung Hee Univ.
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Miyamoto K
Kanazawa Univ. Hospital Ishikawa Jpn
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Choi Jeongeun
College Of Pharmacy Kyungsung University
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Sohn Ll-cheol
College Of Pharmacy Kyung Hee University
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Itoh Yoshie
Department Of Hospital Pharmacy School Of Medicine Kanazawa University
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Itoh Yoshie
Department Of Hematology Gifu Prefectural Tajimi Hospital
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Miyamoto Ken-ichi
Department Of Applied Pharmacology Faculty Of Pharmaceutical Sciences Hokuriku University
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