Role of Low Protein and Low Phosphorus Diet in the Progression of Chronic Kidney Disease in Uremic Rats
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概要
- 論文の詳細を見る
Restriction of dietary protein is useful for chronic kidney disease (CKD) patients to protect residual renal function. However, the mechanism by which a low protein diet confers a beneficial effect in CKD patients remains unknown. One possibility is that the benefit from a low protein diet is associated with phosphorus restriction. The aim of this study is to compare the effect of protein and phosphorus on the progression of renal insufficiency using irreversible Thyl rats, which histopathologically resemble IgA nephropathy. Irreversible Thyl rats were fed six types of isocaloric diets consisting of three levels of protein (16.9, 12.6, and 8.4%) and two levels of phosphorus (0.5 and 0.3%) for 13 wk. Renal function was assessed biochemically and histopathologically. The low phosphorus (0.3%) diets showed protection of residual renal function regardless of dietary protein content in uremic rats. With the normal phosphorus (0.5%) diets, however, only the very low protein (8.4%) diet showed a beneficial effect, indicating that dietary phosphorus is a more important factor that affects the progression of renal insufficiency than dietary protein in this model. Furthermore, the low phosphorus diet also prevented an increase in serum parathyroid hormone, indicating that a low phosphorus diet might have beneficial effects not only for residual renal function but also for renal osteodystrophy, a typical complication of patients with CKD.
- 日本ビタミン学会の論文
著者
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Kusano Kenichiro
中外製薬
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Kusano Kenichiro
Pharmaceutical Research Department I Chugai Pharmaceutical Co. Ltd.
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MIYAMOTO Ken-ichi
Department of Pharmacology and Pharmaceutics, Graduate School of Natural Science and Technology, Kan
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Miyamoto Ken-ichi
Department Of Molecular Nutrition Institute Of Health Bioscience University Of Tokushima Graduate Sc
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Miyamoto Ken-ichi
Department Of Molecular Nutrition Institute Of Health Biosciences The University Of Tokushima Gradua
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SEGAWA Hiroko
Department of Molecular Nutrition, Institute of Health Biosciences, University of Tokushima Graduate
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Segawa Hiroko
Department Of Molecular Nutrition Institute Of Health Bioscience University Of Tokushima Graduate Sc
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Segawa Hiroko
Department Of Molecular Nutrition Institute Of Health Biosciences The University Of Tokushima Gradua
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Morita Kyoko
Department Of Clinical Nutrition School Of Medicine The University Of Tokushima
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FUKUSHIMA Naoshi
Pharmaceutical Research Department I, Chugai Pharmaceutical Co., Ltd.
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OHNISHI Ritsuko
Department of Molecular Nutrition, Institute of Health Bioscience, University of Tokushima Graduate
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Miyamoto Ken-ichi
Department Of Applied Pharmacology Faculty Of Pharmaceutical Sciences Hokuriku University
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Segawa Hiroko
Nutritional Science Department Of Nutrition School Of Medicine Tokushima University
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Fukushima Naoshi
Pharmaceutical Research Department I Chugai Pharmaceutical Co. Ltd.
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Ohnishi Ritsuko
Department Of Molecular Nutrition Institute Of Health Bioscience University Of Tokushima Graduate Sc
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