Supplementation of Fat Emulsion Improves Fatty Liver due to Total-Parenteral Nutrition in Young Adult Rats
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概要
- 論文の詳細を見る
Conscious young adult male rats were given total-parenteral nutrition (TPN) with or without a soybean fat emulsion for 4 days and those that did not receive the emulsion (fat-free TPN group) developed severe fatty liver with hyperglycemia, hyperinsulinemia, and hypotriglyceridemia. These disorders were improved by administering TPN supplemented with soybean fat, equivalent to 20% of total calories, with glucose correspondingly reduced. In the fat-free TPN group, the expression of sterol regulatory element binding protein 1c (SREBP1c), acetyl-CoA carboxylase (ACC), and fatty acid synthase (FAS) mRNAs in the liver were coordinately up-regulated, resulting in an increase in non-essential fatty acids and a decrease in essential fatty acids in the liver, due to the fat supply drying up. In contrast, expression of carnitine-palmitoyltransferase (CPT) la mRNA decreased. However, in the group given the fat emulsion in their TPN, the expressions of all of the above types of mRNA remained similar to those in an oral diet control group. It appeared that the hyperinsulinemia following infusion of excess glucose had induced lipogenesis and a decrease in fatty acid β-oxidation in the liver and that these changes were prevented by supplementation of soybean fat equivalent to 20% of total calories (with a corresponding reduction in glucose). Therefore, it may be appropriate to routinely supplement fat-free TPN with soybean fat in the clinical situation, substituting it for part of the glucose. In addition, serum glucose and insulin levels should be monitored during TPN infusions.
- 日本医療薬学会の論文
- 2008-07-10
著者
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OMURA Kenji
Department of General and Cardiothoracic Surgery, Kanazawa University Graduate School of Medicine
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MIYAMOTO Ken-ichi
Department of Pharmacology and Pharmaceutics, Graduate School of Natural Science and Technology, Kan
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YOKOGAWA Koichi
Department of Hospital Pharmacy, School of Medicine, Kanazawa University
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Omura Kenji
Department Of General And Cardiothoracic Surgery Kanazawa University Graduate School Of Medicine
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Yokogawa Koichi
Department Of Clinical Pharmacy Graduate School Of Natural Science And Technology Kanazawa Universit
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Miyaamoto Ken-ichi
Department Of Medical Informatics Graduate School Of Medical Science Kanazawa University
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Miyamoto K
Kanazawa Univ. Hospital Ishikawa Jpn
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Yokogawa Koichi
Department Of Chemistry Faculty Of Pharmaceutical Sciences Hokuriku University
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Ohkawa Hiroko
Department of Clinical Pharmacy, Graduate School of Natural Science and Technology, Kanazawa Univers
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Fukuwa Chie
Department of Clinical Pharmacy, Graduate School of Natural Science and Technology, Kanazawa Univers
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Matsuzawa-Nagata Naoto
Department of Clinical Pharmacy, Graduate School of Natural Science and Technology, Kanazawa Univers
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Matsuzawa-nagata Naoto
Department Of Clinical Pharmacy Graduate School Of Natural Science And Technology Kanazawa Universit
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Miyamoto Ken-ichi
Department Of Applied Pharmacology Faculty Of Pharmaceutical Sciences Hokuriku University
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Miyamoto Ken-ichi
Department Of Clinical Pharmacy Graduate School Of Natural Science And Technology Kanazawa Universit
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Fukuwa Chie
Department Of Clinical Pharmacy Graduate School Of Natural Science And Technology Kanazawa Universit
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Ohkawa Hiroko
Department Of Clinical Pharmacy Graduate School Of Natural Science And Technology Kanazawa Universit
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