Preparation and Structure-Activity Relationships of Novel Asterriquinone Derivatives
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概要
- 論文の詳細を見る
Asterriquinone (ARQ, 1a) is an antitumor metabolite of Aspergillus terreus IFO 6123. To gain insight into the structure-activity relationships of ARQ, a series of chemically modified derivatives (1-6), the ARQ analogues (b-e) and the 2,5-dihydroxy-p-bezoquinone analogues (f-h), were prepared, and cytotoxic acitivity against mouse leukemia P388 cells investigated. Results indicated that : 1) at least one hydroxy group or acetoxy group in the p-benzoquinone moiety is important to exhibit cytotoxicity; 2) in the p-benzoquinone moiety, a single methoxy group and/or one aceotxy group substitution showed more potent cytotoxicity than when two hydroxy groups are substituted (1); 3) the indole ring is important for the cytotoxicity of ARQ analogues; 4) the 1,1-dimethly-2-propenyl group in the indole ring is not important for the cytotoxic activity of ARQ.
- 公益社団法人日本薬学会の論文
- 1998-08-15
著者
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鍛治 聡
Faculty of Pharmaceutical Sciences, Hokuriku University
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桐山 典城
Faculty of Pharmaceutical Sciences, Hokuriku University
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Nomura M
Department Of Clinical Pharmacology Faculty Of Pharmaceutical Sciences Hokuriku University
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Nomura Masaaki
Graduate School Of Natural Science And Technology Kanazawa University
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MIYAMOTO Ken-ichi
Graduate School of Natural Science and Technology, Kanazawa University
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KAJI Akira
Faculty of Pharmaceutical Sciences, Hokuriku University
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KIRIYAMA Noriki
Faculty of Pharmaceutical Sciences, Hokuriku University
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KIMURA Kengo
Faculty of Pharmaceutical Sciences, Hokuriku University
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TERANISHI Masanori
Faculty of Pharmaceutical Sciences, Hokuriku University
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Miyamoto Ken-ichi
Department Of Hospital Pharmacy School Of Medicine Kanazawa University
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Miyaamoto Ken-ichi
Department Of Medical Informatics Graduate School Of Medical Science Kanazawa University
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Miyamoto Ken-ichi
Graduate School Of Natural Science And Technology Kanazawa University
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桐山 典城
Faculty Of Pharmaceutical Sciences Hokuriku University
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Kaji A
Faculty Of Pharmaceutical Sciences Hokuriku University
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鍛治 聡
Faculty Of Pharmaceutical Sciences Hokuriku University
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Kimura Kengo
Faculty Of Pharmaceutical Sciences Hokuriku University
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Miyamoto K
Kanazawa Univ. Hospital Ishikawa Jpn
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Kiriyama N
Faculty Of Pharmaceutical Sciences Hokuriku University
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Teranishi M
Faculty Of Pharmaceutical Sciences Hokuriku University
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Miyamoto Ken-ichi
Graduate School Of Natural Sci. And Technol. Kanazawa Univ.
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