Effects of 1-Benzylxanthines on Cyclic AMP Phosphodiesterase 4 Isoenzyme(Medicinal Chemistry)

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概要

• 論文の詳細を見る

• Based on our results regarding the structure-activity relationships of alkylxanthines and imidazo [2, 1-i] purines as phosphodiesterase 4 (PDE4) inhibitors, we designed new 1-benzylxanthines and investigated their PDE4 inhibitory activities. 3, 7-Dihydro-7-acetonyl-1-(2, 4-dichlorobenzyl)-3-propyl-1H-purine-2, 4-dione (2h) exhibited both more selective and more potent PDE4 inhibitory activity than rolipram and XT-611.

• 社団法人日本薬学会の論文
• 2006-01-01

著者

• NOMURA Masaaki

  Department of Pharmacology and Pharmaceutics, Graduate School of Natural Science and Technology, Kan

• MIYAMOTO Ken-ichi

  Department of Pharmacology and Pharmaceutics, Graduate School of Natural Science and Technology, Kan

• Sawanishi Hiroyuki

  Department Of Medicinal Chemistry Faculty Of Pharmaceutical Sciences Hokuriku University

• Sawanishi H

  Hokuriku Univ. Kanazawa

• Shimada Tsutomu

  Research Institute Of Pharmaceutical Sciences Musashino University

• Nomura M

  Department Of Clinical Pharmacology Faculty Of Pharmaceutical Sciences Hokuriku University

• Nomura Masaaki

  Graduate School Of Natural Science And Technology Kanazawa University

• Nomura Masaaki

  Department Of Clinical Pharmacology Faculty Of Pharmaceutical Sciences Hokuriku University

• Suzuki Hideyo

  Toyama Prefectural Institute For Pharmaceutical Research

• Suzuki H

  Toyama Prefectural Institute For Pharmaceutical Research

• Suzuki H

  Department Of Medicinal Chemistry Faculty Of Pharmaceutical Sciences Hokuriku University

• SUZUKI Hirokazu

  Department of Medicinal Chemistry, Faculty of Pharmaceutical Sciences, Hokuriku University

• SHIMADA Tsutomu

  Department of Hospital Pharmacy, School of Medicine, Kanazawa University

• Miyamoto Ken-ichi

  Department Of Hospital Pharmacy School Of Medicine Kanazawa University

• Miyaamoto Ken-ichi

  Department Of Medical Informatics Graduate School Of Medical Science Kanazawa University

• Miyamoto Ken-ichi

  Graduate School Of Natural Science And Technology Kanazawa University

• Sawanishi Hiroyuki

  Faculty Of Pharmaceutical Sciences Hokuriku University

• Suzuki H

  Janssen Pharmaceutical K.k. Shizuoka Jpn

• Suzuki Hirokazu

  Department Of Biomolecular Engineering Graduate School Of Engineering Tohoku University

• Shimada Tsutomu

  Res. Inst. Of Pharmaceutical Sciences Musashino Univ.

• Miyamoto K

  Kanazawa Univ. Hospital Ishikawa Jpn

• Sawanishi H

  Department Of Medicinal Chemistry Faculty Of Pharmaceutical Sciences Hokuriku University

• Miyamoto Ken-ichi

  Department Of Applied Pharmacology Faculty Of Pharmaceutical Sciences Hokuriku University

• Suzuki Hirokazu

  Department Of Applied Chemistry College Of Engineering Chubu University

• Shimada Tsutomu

  Department Of Hospital Pharmacy School Of Medicine Kanazawa University

• Shimada Tsutomu

  Department Of Chemical Biology Osaka City University Medical School

• Suzuki Hirokazu

  Department Of Medicinal Chemistry Faculty Of Pharmaceutical Sciences Hokuriku University

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