Characteristic Properties of Genipin as an Activator in Neuronal Nitric Oxide Synthase
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概要
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The present investigation was undertaken to compare the structural and electronic properties of genipin with those of tetrahydrobiopterin (H_4B), an essential cofactor in neuronal nitric oxide synthase (nNOS), and 4-aminotetrahydrobiopterin (4-amino-H_4B), an inhibitor of nNOS, using computer-assisted molecular modeling techniques. Molecular modeling, superimposing, and docking simulation, in addition to LUMO-energy calculation, revealed that genipin has structural and electronic properties that markedly resemble those of H_4B.
- 社団法人日本薬学会の論文
- 2007-12-01
著者
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Chiba Kenzo
Department Of Biodynamics Faculty Of Pharmaceutical Sciences Hokuriku University
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Chiba Kenzo
Department Of Biochemistry Faculty Of Pharmaceutical Sciences Hokuriku University
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Yamazaki Matsumi
Department Of Biodynamics Faculty Of Pharmaceutical Sciences Hokuriku University
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Sawanishi Hiroyuki
Department Of Medicinal Chemistry Faculty Of Pharmaceutical Sciences Hokuriku University
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SUZUKI Hirokazu
Department of Medicinal Chemistry, Faculty of Pharmaceutical Sciences, Hokuriku University
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Sawanishi Hiroyuki
Department Of Medicinal Chemistry Faculty Of Pharmaceutical Sciences:organization For Frontier Resea
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Chiba Kenzo
Department Of Biochemistry Faculty Of Pharmaceutical Science Hokuriku University:department Of Organ
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Suzuki Hirokazu
Department Of Biomolecular Engineering Graduate School Of Engineering Tohoku University
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Yamazaki Matsumi
Department Of Biochemistry Faculty Of Pharmaceutical Science Hokuriku University
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Suzuki Hirokazu
Department Of Applied Chemistry College Of Engineering Chubu University
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Sawanishi Hiroyuki
Department Of Medicinal Chemistry Hokuriku University
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Yamazaki Matsumi
Department of Biochemistry, Faculty of Pharmaceutical Sciences
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Chiba Kenzo
Department of Biochemistry, Faculty of Pharmaceutical Sciences:Organization for Frontier Research in Preventive Pharmaceutical Sciences, Hokuriku University
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Suzuki Hirokazu
Department of Medicinal Chemistry, Faculty of Pharmaceutical Sciences:Organization for Frontier Research in Preventive Pharmaceutical Sciences, Hokuriku University
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