Neuritogenesis of Herbal Geniposide-Related Compounds in PC12h Cells
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概要
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Previously, we have reported that geniposide, a compound isolated from an extract of Gardenia fructus, has neuritogenic activity in PC12h cells, a subclone of the rat pheochromocytoma cell. In this study, we have examined the effects of seven geniposide-related compounds (S-1, 6α-hydroxygeniposide; S-2, 6β-hydroxygeniposide; S-3, 6α-methoxygeniposide; S-4, 6β-methoxygeniposide; S-5, loganin; S-6, 7-ketologanin; and S-7, syringopicroside) isolated from various medicinal herbs. The geniposide-type iridoids S-1, S-2, S-3, and S-4, and S-7 induced neurite outgrowth that was similar or more potent to that of geniposide. S-2 and S-4, which are optical isomers of S-1 and S-3, respectively, were particularly potent. The 2 loganin-type iridoids, S-5 and S-6, showed less activity than geniposide. The neuritogenic activity of geniposide-type iridoids appears to be not necessarily correlated directly to their hydrophobicity. These results suggest that geniposide-type iridoids have potent neuritogenic activity and that specific configurations for the interactions between iridoid compounds and the target molecule are necessary for neuritogenic function.
- 社団法人日本薬学会の論文
- 2006-12-01
著者
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MACHIDA Koichi
Tohoku Pharmaceutical University
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KIKUCHI Masao
Tohoku Pharmaceutical University
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Chiba Kenzo
Department Of Biodynamics Faculty Of Pharmaceutical Sciences Hokuriku University
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Yamazaki Matsumi
Department Of Biodynamics Faculty Of Pharmaceutical Sciences Hokuriku University
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Kikuchi M
東北薬科大学
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KIKUCHI Masafumi
Tohoku Pharmaceutical University
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Kikuchi Masao
Tohoku College Of Pharmacy
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Chiba Kenzo
Department Of Biochemistry Faculty Of Pharmaceutical Science Hokuriku University:department Of Organ
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Machida Koichi
Tohoku College Of Pharmacy
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Yamazaki Matsumi
Department Of Biochemistry Faculty Of Pharmaceutical Science Hokuriku University
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Kikuchi Tomoyuki
Tohoku Pharmaceutical University
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