Neuritogenic Activities of 1-Alkyloxygenipins
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概要
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We designed 1-alkyloxygenipins with the aim of improving the stability of genipins based on the structural and electronic properties of genipins, and prepared 1-alkyloxygenipins and examined their neuritogenic activities in PC12h cells. All genipin-derivatives exhibited electronic properties similar to those of genipin and induced significant neurite outgrowth. These compounds will be classified as nitric oxide synthase (NOS) activators (neuritogenic active compounds) since their lowest unoccupied molecular orbital (LUMO)-energies are similar to that of tetrahydrobiopterin (H4B). (1R)-isoPropyloxygenipin showed activity comparable to that of genipin, and unlike the parent compound genipin, it was found to be physiologically stable in rat liver homogenate.
- 社団法人 日本薬学会の論文
著者
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Chiba Kenzo
Department Of Biodynamics Faculty Of Pharmaceutical Sciences Hokuriku University
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Chiba Kenzo
Department Of Biochemistry Faculty Of Pharmaceutical Sciences Hokuriku University
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Yamazaki Matsumi
Department Of Biodynamics Faculty Of Pharmaceutical Sciences Hokuriku University
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SUZUKI Hirokazu
Department of Medicinal Chemistry, Faculty of Pharmaceutical Sciences, Hokuriku University
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Uemori Yoshio
Department of Physical Chemistry, Faculty of Pharmaceutical Sciences, Hokuriku University
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Sawanishi Hiroyuki
Organization for Frontier Research in Preventive Pharmaceutical Sciences, Hokuriku University
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Chiba Kenzo
Department Of Biochemistry Faculty Of Pharmaceutical Science Hokuriku University:department Of Organ
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Suzuki Hirokazu
Department Of Biomolecular Engineering Graduate School Of Engineering Tohoku University
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Yamazaki Matsumi
Department Of Biochemistry Faculty Of Pharmaceutical Science Hokuriku University
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Suzuki Hirokazu
Department Of Applied Chemistry College Of Engineering Chubu University
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Chiba Kenzo
Department of Biochemistry, Faculty of Pharmaceutical Sciences, Hokuriku University
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