Neuro2a Cell Death Induced by 6-Hydroxydopamine is Attenuated by Genipin
スポンサーリンク
概要
- 論文の詳細を見る
We have previously reported that genipin, a natural iridoid compound, shows neuritogenic activity in cultured rat pheochromocytoma PC12h and mouse neuroblastoma Neuro2a cells. 6-Hydroxydopamine (6-OHDA) is a dopaminergic neurotoxin putatively involved in the pathogenesis of Parkinson's disease (PD). Here, we studied the protective effects of genipin on 6-OHDA-induced cytotoxicity in Neuro2a cells. 6-OHDA treatment markedly reduced Neuro2a cell viability in a concentration-dependent manner causing DNA condensation and fragmentation. Genipin significantly protected the cells against the 6-OHDA-induced cytotoxicity. Genipin also protected the cells against hydrogen peroxide (H_2O_2)-induced cytotoxicity. It is known that 6-OHDA is rapidly and non-enzymatically oxidized by molecular oxygen to form H_2O_2 and the corresponding p-quinone. These data suggest that genipin is effective at protecting against neurodegeneration that involves oxidative stress, such as PD.
- 社団法人日本薬学会の論文
- 2008-12-01
著者
-
Chiba Kenzo
Department Of Biodynamics Faculty Of Pharmaceutical Sciences Hokuriku University
-
Yamazaki Matsumi
Department Of Biodynamics Faculty Of Pharmaceutical Sciences Hokuriku University
-
Satoh Keiko
Department of Biochemistry, Faculty of Pharmaceutical Sciences, Hokuriku University
-
Chiba Kenzo
Department Of Biochemistry Faculty Of Pharmaceutical Science Hokuriku University:department Of Organ
-
Satoh Keiko
Department Of Biochemistry Faculty Of Pharmaceutical Sciences Hokuriku University
-
Yamazaki Matsumi
Department Of Biochemistry Faculty Of Pharmaceutical Science Hokuriku University
-
Chiba Kenzo
Department Of Biochemistry Faculty Of Pharmaceutical Sciences Hokuriku University:organization For F
関連論文
- Neuritogenesis of Herbal Geniposide-Related Compounds in PC12h Cells
- Neuritogenic Activities of 1-Alkyloxygenipins
- Characteristic Properties of Genipin as an Activator in Neuronal Nitric Oxide Synthase
- Neuroprotective Action of Genipin on Tunicamycin-Induced Cytotoxicity in Neuro2a Cells
- Correlation between Neuritogenic Action of Nitric Oxide and the Rate of Nitric Oxide Production in PC12h Cells
- Genipin Suppresses A23187-Induced Cytotoxicity in Neuro2a Cells
- Neuro2a Cell Death Induced by 6-Hydroxydopamine is Attenuated by Genipin
- Expression of Functional Nitric Oxide Synthase for Neuritogenesis in PC12h Cells
- Neurotrophic Effects of Genipin on Neuro2a Cells
- Detection of Genipin/Geniposide-Target Molecules by a Geniposide Overlay Method Using Anti-Geniposide Antibody
- Neuritogenesis of Herbal (+)- and (-)-Syringaresinols Separated by Chiral HPLC in PC12h and Neuro2a Cells
- Prevention of the Neurotoxicity of the Amyloid β Protein by Genipin
- Effect of Polyacetylenes on the Neurite Outgrowth of Neuronal Culture Cells and Scopolamine-Induced Memory Impairment in Mice
- Evaluation of Neurotoxicity of Alzheimer's Amyloid β protein (β42) in Cultured Hippocampal Cells and Its Prevention by Propentofylline
- Neuritogenic Effect of Natural Iridoid Compounds on PC12h Cells and Its Possible Relation to Signaling Protein Kinases
- New physiological function of secoiridoids : neuritogenic activity in PC12h cells