Prevention of the Neurotoxicity of the Amyloid β Protein by Genipin
スポンサーリンク
概要
- 論文の詳細を見る
Genipin, which was shown in our previous investigation to have prominent neuritogenic activity in paraneurons such as PC12h cells, was studied to determine whether it could prevent the toxicity of Alzheimer's amyloid β protein(Aβ)in cultured hippocampal neurons. Increased release of lactate dehydrogenase from hippocampal neurons after 2d of Aβ25-35 administration was prevented dose dependentIy by the addition or genipin 20-40μM. Morphological observations and trypan blue staining of cells confirmed the protection of hippocampal neurons from Aβ toxicity by genipin. Geniposide had less effect in preventing Aβ toxicity.
- 公益社団法人日本薬学会の論文
- 2001-12-01
著者
-
Chiba Kenzo
Department Of Biodynamics Faculty Of Pharmaceutical Sciences Hokuriku University
-
Chiba Kenzo
Department Of Biochemistry Faculty Of Pharmaceutical Sciences Hokuriku University
-
Yamazaki Matsumi
Department Of Biodynamics Faculty Of Pharmaceutical Sciences Hokuriku University
-
Sakura Naoki
北陸大学 薬 生物活性
-
Sakura Naoki
Department Of Biosynthetic Chemistry Faculty Of Pharmaceutical Science Hokuriku University
-
Sakura Naoki
Department Of Bio-organic Chemistry Faculty Of Pharmaceutical Sciences Hokuriku University
-
Yamazaki M
School Of Pharmaceutical Sciences Kinki University
-
Mohri Tetsuro
Department of Biodynamics, Faculty of Pharmaceutical Sciences, Hokuriku University
-
Chiba Kenzo
Department Of Biochemistry Faculty Of Pharmaceutical Science Hokuriku University:department Of Organ
-
Mohri Tetsuro
Department Of Biodynamics Faculty Of Pharmaceutical Sciences Hokuriku University
-
Yamazaki Matsumi
Department Of Biochemistry Faculty Of Pharmaceutical Science Hokuriku University
関連論文
- Brazilian Natural Medicines. III. Structures of Triterpene Oligoglycosides and Lipase Inhibitors from Mate, Leaves of Ilex paraguariensis
- Medicinal Flowers. XXVI. Structures of Acylated Oleanane-Type Triterpene Oligoglycosides, Yuchasaponins A, B, C, and D, from the Flower Buds of Camellia oleifera : Gastroprotective, Aldose Reductase Inhibitory, and Radical Scavenging Effects
- Medicinal Flowers. XXI. : Structures of Perennisaponins A, B, C, D, E, and F, Acylated Oleanane-Type Triterpene Oligoglycosides, from the Flowers of Bellis perennis
- Medicinal Flowers. XXVII : New Flavanone and Chalcone Glycosides, Arenariumosides I, II, III, and IV, and Tumor Necrosis Factor-α Inhibitors from Everlasting, Flowers of Helichrysum arenarium
- Structures of Acetylated Oleanane-Type Triterpene Saponins, Rarasaponins IV, V, and VI, and Anti-hyperlipidemic Constituents from the Pericarps of Sapindus rarak
- Absolute Stereostructures of Olibanumols A, B, C, H, I, and J from Olibanum, Gum-Resin of Boswellia carterii, and Inhibitors of Nitric Oxide Production in Lipopolysaccharide-Activated Mouse Peritoneal Macrophages
- Medicinal Flowers. XXIV. Chemical Structures and Hepatoprotective Effects of Constituents from Flowers of Hedychium coronarium
- Medicinal Flowers. XXIII. New Taraxastane-Type Triterpene, Punicanolic Acid, with Tumor Necrosis Factor-α Inhibitory Activity from the Flowers of Punica granatum
- Bioactive Constituents from Chinese Natural Medicines. XXXII : Aminopeptidase N and Aldose Reductase Inhibitors from Sinocrassula indica: Structures of Sinocrassosides B_4, B_5, C_1, and D_1-D_3
- Medicinal Foodstuffs. XXXIV. : Structures of New Prenylchalcones and Prenylflavanones with TNF-α and Aminopeptidase N Inhibitory Activities from Boesenbergia rotunda
- Bioactive Constituents from Chinese Natural Medicines. XXVI : Chemical Structures and Hepatoprotective Effects of Constituents from Roots of Rhodiola sachalinensis
- Bioactive Constituents from Chinese Natural Medicines. XXIV. : Hypoglycemic Effects of Sinocrassula indica in Sugar-Loaded Rats and Genetically Diabetic KK-A^y Mice and Structures of New Acylated Flavonol Glycosides, Sinocrassosides A_1, A_2, B_1, and B_2
- New Toxic Metabolites from a Mushroom, Hebeloma vinosophyllum. II. Isolation and Structures of Hebevinosides VI, VII, VIII, IX, X, and XI(Organic,Chemical)
- New Toxic Metabolites from a Mushroom, Hebeloma vinosophyllum. I. : Structures of Hebevinosides I, II, III, IV, and V
- 69 アカヒダワカフサタケの毒性代謝産物hebevinoside類の単離と構造(その2)
- 9 アカヒダワカフサタケの毒性代謝産物hebevinoside類の単離と構造
- THE TOXIC PRINCIPLES OF NAEMATOLOMA FASCICULARE
- Chemistry of Tremorogenic Metabolites. II. Structure Determination of Fumitremorgin B, a Tremorogenic Metabolite from Aspergillus fumigatus
- Development of Des-Fatty Acyl-Polymyxin B Decapeptide Analogs with Pseudomonas aeruginosa-Specific Antimicrobial Activity
- Contribution of Each Amino Acid Residue in Polymyxin B_3 to Antimicrobial and Lipopolysaccharide Binding Activity
- Des-Fatty Acyl-Polymyxin B Decapeptide Analogs with Antimicrobial Activity Specifically against Pseudomonas aeruginosa
- Semi-synthesis of Polymyxin B (2-10) and Colistin (2-10) Analogs Employing the Trichloroethoxycarbonyl (Troc) Group for Side Chain Protection of α, γ-Diaminobutyric Acid Residues
- Chemical Conversion of Natural Polymyxin B and Colistin to Their N-Terminal Derivatives
- Semi-Synthesis of Polymyxin B-(2-10) Analogs Employing the Trichloroethoxycarbonyl (Troc) Group for Side Chain Protection of 2,4-Diaminobutyric Acid Residues
- Structure-Activity Relationships of Neuromedin U. V. Study on the Stability of Porcine Neuromedin U-8 at the C-Terminal Asparagine Amide under Mild Alkaline and Acidic Conditions
- Antimicrobial Activity of Des-Fatty Acyl-Polymyxin B Decapeptide N-Terminal Analogs
- The Contribution of the N-Terminal Structure of Polymyxin B Peptides to Antimicrobial and Lipopolysaccharide Binding Activity
- Hydrolytic Cleavage of Pyroglutamyl-peptide Bond. V. Selective Removal of Pyroglutamic Acid from Biologically Active Pyroglutamylpeptides in High Concentrations of Aqueous Methanesulfonic Acid
- Isolation and Structure Determination of [Ile^7]- and [Ser^2]-Polymyxin B_1
- Antimicrobial Activity of Polymyxin B_3 Analogs modified at the Hydrophobic Amino Acids
- HPLC Analysis of Fatty Acyl-Glycine in the Aqueous Methanesulfonic Acid Hydrolysates of N-Terminally Fatty Acylated Peptides(Analytical Biochemistry)
- HPLC Analysis of Fatty Acylglycine in the Hydrolysates of N-Terminally Blocked Peptides by Fatty Acids
- Apoptosis-Inducing Effects of Sterols from the Dried Powder of Cultured Mycelium of Cordyceps sinensis
- Bioactive Constituents from Chinese Natural Medicines. XXIII. Absolute Structures of New Megastigmane Glycosides, Sedumosides A_4, A_5, A_6, H, and I, and Hepatoprotective Megastigmanes from Sedum sarmentosum
- Bioactive Constituents from Chinese Natural Medicines. XXII. Absolute Structures of New Megastigmane Glycosides, Sedumosides E_1, E_2, E_3, F_1, F_2, and G, from Sedum sarmentosum (Crassulaceae)
- Bioactive Saponins and Glycosides. XXVIII. New Triterpene Saponins, Foliatheasaponins I, II, III, IV, and V, from Tencha (the Leaves of Camellia sinensis)
- P-469 ANTI-ALLERGIC AND ANTI-INFLAMMATORY ACTIVITIES OF 1'S-1'-ACETOXYCHAVICOL ACETATE AND RELATED COMPOUNDS
- P-466 ACYLATED PHENETHYLGLYCOSIDES WITH VASORELAXANT ACTIVITY FROM CISTANCHE TUBULOSA
- P-298 SYNTHESIS OF 1,5-ANHYDRO-5-AZA-D-GLUCITOL ANALOGS OF SALACINOL AND THEIR α-GLUCOSIDASE INHIBITORY ACTIVITIES
- Monoterpene Constituents from Cistanche tubulosa : Chemical Structures of Kankanosides A-E and Kankanol
- Inhibitors of Nitric Oxide Production from the Rhizomes of Alpinia galanga : Structures of New 8-9' Linked Neolignans and Sesquineolignan
- Antidiabetogenic constituents from Salacia species(Chemical & Pharmacological study)
- Synthesis of a Nitrogen Analogue of Salacinol and Its α-Glucosidase Inhibitory Activity
- Saponins of Plants of Panax Species Collected in Central Nepal, and Their Chemotaxonomical Significance. III.
- Study on Anti-Oketsu Activity of Rhubarb II. Anti-allergic Effects of Stillbene Components from Rhei undulati Rhizoma(Dried Rhizome of Rheum undulatum Cultivated in Korea)
- Studies on Alismatis Rhizoma. III. Stereostructures of New Protostane-Type Triterpenes, Alisols H, I, J-23-Acetate, K-23-Acetate, L-23-Acetate, M-23-Acetate, and N-23-Acetate, from the Dried Rhizome of Alisma orientale
- Hepatoprotective and Antioxidative Properties of Salacia reticulata : Preventive Effects of Phenolic Constituents on CCl_4-Induced Liver Injury in Mice
- Medicinal Foodstuffs. XVIII. Phytoestrogens from the Aerial Part of Petroselinum crispum MILL. (PARSLEY) and Structures of 6"-Acetylapiin and a New Monoterpene Glycoside, Petroside
- Medicinal Flowers. II. Inhibitors of Nitric Oxide Production and Absolute Stereostructurs of Five New Germacrane-Type Sesquiterpenes, Kikkanols D, D Monoacetate, E, F, and F Monoacetate from the Flowers of Chrysanthemum indicum L.
- Chemical Constituents from the Leaves of Hydrangea macrophylla var. thunbergii(III) : Absolute Stereostructures of Hydramacrosides A and B, Secoiridoid Glucoside Complexes with Inhibitory Activity on Histamine Release
- The Role of Thunberginol A, an Isocoumarin Constituent of Hydrangeae Dulcis Folium, on the Signal Transmission Pathway for Rat Mast Cell Degranulation
- Effects of Phyllodulcin, Hydrangenol, and Their 8-O-Glucosides, and Thunberginols A and F from Hydrangea macrophylla SERINGE var. thunbergii MAKINO on Passive Cutaneous Anaphylaxis Reaction in Rats
- Medicinal Foodstuffs. XXIV.^ Chemical Constituents of the Processed Leaves of Apocynum venetum L. : Absolute Stereostructures of Apocynosides I and II
- Syntheses of Antifungal Isocoumarins. III. Synthesis and Antifungal Activity of 3-Aryl-3,4-dihydro-4-substituted-isocoumarins
- Antifungal Activity of Oosponol, Oospolactone, Phyllodulcin, Hydrangenol, and Some Other Related Compounds
- Syntheses of Antifungal Isocoumarins. II. Synthesis and Antifungal Activity of 3-Substituted Isocoumarins
- Medicinal Foodstuffs.XXVII.^ Saponin Constituents of Gotu Kola(2) : Structures of New Ursane- and Oleanane-Type Triterpene Oligoglycosides, Centellasaponins B, C, and D, from Centella asiatica Cultivated in Sri Lanka
- Melanogenesis Stimulation in Murine B16 Melanoma Cells by Umberiferae Plant Extracts and Their Coumarin Constituents(Pharmacognosy)
- P-328 MOLECULAR CLONING AND CHARACTERIZATION OF BITTER-SPECIFIC GENES FROM LUPINUS ANGUSTIFOLIUS
- Medicinal Flowers. VI. : Absolute Stereostructures of Two New Flavanone Glycosides and a Phenylbutanoid Glycoside from the Flowers of Chrysanthemum indicum L. : Their Inhibitory Activities for Rat Lens Aldose Reductase
- Neuritogenesis of Herbal Geniposide-Related Compounds in PC12h Cells
- Inhibitory Effects of Thunberginols A, B, and F on Degranulations and Releases of TNF-α and IL-4 in RBL-2H3 Cells(Pharmacognosy)
- Cross Sections of Charge Exchange for Fast He Ions Passing through Zn Vapor
- Neuritogenic Activities of 1-Alkyloxygenipins
- Characteristic Properties of Genipin as an Activator in Neuronal Nitric Oxide Synthase
- Neuroprotective Action of Genipin on Tunicamycin-Induced Cytotoxicity in Neuro2a Cells
- Correlation between Neuritogenic Action of Nitric Oxide and the Rate of Nitric Oxide Production in PC12h Cells
- Genipin Suppresses A23187-Induced Cytotoxicity in Neuro2a Cells
- Neuro2a Cell Death Induced by 6-Hydroxydopamine is Attenuated by Genipin
- Expression of Functional Nitric Oxide Synthase for Neuritogenesis in PC12h Cells
- Neurotrophic Effects of Genipin on Neuro2a Cells
- P-41 防風の鎮痛活性成分 II.
- Sesquiterpenes from Curcuma comosa
- Structures of New Sesquiterpenes from Curcuma comosa
- Melanogenesis Stimulation in Murine B16 Melanoma Cells by Piper nigrum Leaf Extract and Its Lignan Constituents(Pharmacognosy)
- Anti-androgenic and Hair Growth Promoting Activities of Lygodii Spora (Spore of Lygodium japonicum)I. : Active Constituents Inhibiting Testosterone 5α-Reductase
- Testosterone 5α-Reductase Inhibitory Active Constituents from Anemarrhenae Rhizoma
- Anti-androgenic Activity of Myricae Cortex-Isolation of Active Constituents from Bark of Myrica rubra
- Induction of GM-CSF Production of Macrophages by Advanced Glycation End Products of the Maillard Reaction
- The Effects of Interleukin (IL)-4 and IL-10 on Macrophage Growth-Stimulating Activities of Oxidized Low Density Lipoprotein (LDL), Acetylated LDL and Macrophage Colony-Stimulating Factor : The activity of Oxidized LDL Is Refractory to the Inhibitory Cytok
- Pharmacokinetic advantage of an intranasal preparation of a novel anti-osteoporosis drug, L-Asp-hexapeptide-conjugated estradiol
- NEW FUNGAL METABOLITES AVELLANINS A AND B FROM HAMIGERA AVELLANEA, WITH PRESSOR EFFECT(Communication to the Editor)
- Suppressive Activity of Lycoricidinol (Narciclasine) against Cytotoxicity of Neutrophil-Derived Calprotectin, and Its Suppressive Effect on Rat A djuvant Arthritis Model
- 3 Aspergillus fumigatusより得られたTryptoquivaline関連化合物について
- Synthesis and Antimicrobial Activity of Polymyxin B Component Peptides
- Development of Neuromedin U Agonist with Specifically Potent Contractile Activity on Rat Uterus Smooth Muscle
- 36 食品汚染菌Aspergillus fumigatusより得られた痙攣性代謝産物の化学構造と薬理活性
- Structures of New Friedelane-and Norfriedelane-Type Triterpenes and Polyacylated Eudesmane-Type Sesquiterpene from Salacia chinensis LINN. (S. prinoides DC., Hippocrateaceae) and Radical Scavenging Activities of Principal Constituents
- Medicinal Flowers.III.^ Marigold.(1) : Hypoglycemic, Gastric Emptying Inhibitory, and Gastroprotective Principles and New Oleanane-Type Triterpene Oligoglycosides, Calendasaponins A, B, C and D, from Egyptian Calendula officinalis
- Medicinal Foodstuffs. XIX. Absolute Stereostructures of Canavalioside, a New Ent-Kaurane-Type Diterpene Glycoside, and Gladiatosides A_1,A_2,A_3,B_1,B_2,B_3,C_1,and C_2,New Acylated Flavonol Glycosides, from Sword Bean, the Seeds of Canavalia gladiata
- Detection of Genipin/Geniposide-Target Molecules by a Geniposide Overlay Method Using Anti-Geniposide Antibody
- Neuritogenesis of Herbal (+)- and (-)-Syringaresinols Separated by Chiral HPLC in PC12h and Neuro2a Cells
- Prevention of the Neurotoxicity of the Amyloid β Protein by Genipin
- Effect of Polyacetylenes on the Neurite Outgrowth of Neuronal Culture Cells and Scopolamine-Induced Memory Impairment in Mice
- Evaluation of Neurotoxicity of Alzheimer's Amyloid β protein (β42) in Cultured Hippocampal Cells and Its Prevention by Propentofylline
- Neuritogenic Effect of Natural Iridoid Compounds on PC12h Cells and Its Possible Relation to Signaling Protein Kinases
- Novel Des-Fatty Acyl-Polymyxin B Derivatives with Pseudomonas aeruginosa-Specific Antimicrobial Activity
- Antimicrobial Activity of Various Aminocyclohexylcarbonyl-polymyxin B (2-10) Derivatives
- Structure-Activity Relationships of Neuromedin U.IV. Absolute Requirement of the Arginine Residue at Position 7 of Dog Neuromedin U-8 for Contractile Activity
- New physiological function of secoiridoids : neuritogenic activity in PC12h cells