Prevention of the Neurotoxicity of the Amyloid β Protein by Genipin

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概要

• 論文の詳細を見る

• Genipin, which was shown in our previous investigation to have prominent neuritogenic activity in paraneurons such as PC12h cells, was studied to determine whether it could prevent the toxicity of Alzheimer's amyloid β protein(Aβ)in cultured hippocampal neurons. Increased release of lactate dehydrogenase from hippocampal neurons after 2d of Aβ25-35 administration was prevented dose dependentIy by the addition or genipin 20-40μM. Morphological observations and trypan blue staining of cells confirmed the protection of hippocampal neurons from Aβ toxicity by genipin. Geniposide had less effect in preventing Aβ toxicity.

• 公益社団法人日本薬学会の論文
• 2001-12-01

著者

• Chiba Kenzo

  Department Of Biodynamics Faculty Of Pharmaceutical Sciences Hokuriku University

• Chiba Kenzo

  Department Of Biochemistry Faculty Of Pharmaceutical Sciences Hokuriku University

• Yamazaki Matsumi

  Department Of Biodynamics Faculty Of Pharmaceutical Sciences Hokuriku University

• Sakura Naoki

  北陸大学 薬 生物活性

• Sakura Naoki

  Department Of Biosynthetic Chemistry Faculty Of Pharmaceutical Science Hokuriku University

• Sakura Naoki

  Department Of Bio-organic Chemistry Faculty Of Pharmaceutical Sciences Hokuriku University

• Yamazaki M

  School Of Pharmaceutical Sciences Kinki University

• Mohri Tetsuro

  Department of Biodynamics, Faculty of Pharmaceutical Sciences, Hokuriku University

• Chiba Kenzo

  Department Of Biochemistry Faculty Of Pharmaceutical Science Hokuriku University:department Of Organ

• Mohri Tetsuro

  Department Of Biodynamics Faculty Of Pharmaceutical Sciences Hokuriku University

• Yamazaki Matsumi

  Department Of Biochemistry Faculty Of Pharmaceutical Science Hokuriku University

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