Effect of Polyacetylenes on the Neurite Outgrowth of Neuronal Culture Cells and Scopolamine-Induced Memory Impairment in Mice
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概要
- 論文の詳細を見る
Polyacetylenic alcohols and their linoleates isolated from Panax ginseng C.A.M^<EYER> and Cirsium japonicum DC., of which the lipophilic extracts had been found to affect the neuritogenesis of cultured paraneurons, were demonstrated to have a significant neuritogenic effect on PC12h and Neuro2a cells. Panaxynol and the acetylenic triol in particular were highly efficient at concentrations ≩2μM. Panaxynol(20mg/kg/d, i.p., for 3d)was confirmed to improve scopolamine-induced memory deficit in mice(Y-maze task). It is suggested that the promotion of neuritogenesis in cultured paraneurons by the addition of panaxynol is related its ability to improve memory deficits in animals.
- 公益社団法人日本薬学会の論文
- 2001-12-01
著者
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Chiba Kenzo
Department Of Biodynamics Faculty Of Pharmaceutical Sciences Hokuriku University
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Chiba Kenzo
Department Of Biochemistry Faculty Of Pharmaceutical Sciences Hokuriku University
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Yamazaki Matsumi
Department Of Biodynamics Faculty Of Pharmaceutical Sciences Hokuriku University
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MIYAICHI Yukinori
Department of Pharmacognosy, Pharmaceutical Sciences, Hokuriku University
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Yamazaki M
School Of Pharmaceutical Sciences Kinki University
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HIRAKURA Kazuhiro
Tsumura & Co
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Mohri Tetsuro
Department of Biodynamics, Faculty of Pharmaceutical Sciences, Hokuriku University
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IMAKURA Kimiaki
Department of Biodynamics, Faculty of Pharmacy, Hokuriku University
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KITA Mika
Department of Biodynamics, Faculty of Pharmacy, Hokuriku University
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Chiba Kenzo
Department Of Biochemistry Faculty Of Pharmaceutical Science Hokuriku University:department Of Organ
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Kita Mika
Department Of Biodynamics Faculty Of Pharmacy Hokuriku University
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Mohri Tetsuro
Department Of Biodynamics Faculty Of Pharmaceutical Sciences Hokuriku University
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Yamazaki Matsumi
Department Of Biochemistry Faculty Of Pharmaceutical Science Hokuriku University
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Hirakura Kazuhiro
Tsumura Central Laboratories Tsumura And Co.
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Imakura Kimiaki
Department Of Biodynamics Faculty Of Pharmacy Hokuriku University
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Miyaichi Yukinori
Department Of Pharmacognosy Faculty Of Pharmacy Hokuriku University
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