New Toxic Metabolites from a Mushroom, Hebeloma vinosophyllum. I. : Structures of Hebevinosides I, II, III, IV, and V
スポンサーリンク
概要
- 論文の詳細を見る
The structures of hebevinosides I, II, III, IV, and V, new metabolites from a poisonous mushroom, Hebeloma vinosophyllum, were deduced to be 3β, 16β-dihydroxy-7β-methoxycucurbita-5,24-diene-3-O-β-D-xylopyranoside-16-O-(6-O-acetyl)-β-D-glucopyranoside (1), 3β, 7β, 16β-trihydroxycucurbita-5,24-diene-3-O-(4-O-acetyl)-β-D-xylopyranoside-16-O-(6-O-acetyl)-β-D-glucopyranoside (22), 3β, 7β, 16β-trihydroxycucurbita-5,24-diene-3-O-β-D-xylopyranoside-16-O-(6-O-acetyl)-β-D-glucopyranoside (24), 3β, 16β-dihydroxy-7βmethoxycucurbita-5,24-diene-3-O-β-D-xylopyranoside (16), and 3β, 16β-dihydroxy-7β-methoxycucurbita-5,24-diene-3-O-(4-O-acetyl)-β-D-xylopyranoside-16-O-(6-O-acetyl)-β-D-glucopyranoside (27), respectively, on the basis of chemical and spectral evidence, as well as the structure determination by X-ray crystallographic analysis of ethoxyhebevinogenin (20), obtained by enzymatic hydrolysis of 16. Hebevinosides I, II, III, and V were proved to be toxic principles of this mushroom.
- 社団法人日本薬学会の論文
- 1986-01-25
著者
-
鈴木 久美子
千葉大学薬学部
-
藤本 治宏
Research Institute for Chemobiodynamics, Chiba University
-
萩原 秀美
Research Institute for Chemobiodynamics, Chiba University
-
鈴木 久美子
Research Institute for Chemobiodynamics, Chiba University
-
山崎 幹夫
Research Institute for Chemobiodynamics, Chiba University
-
藤本 治宏
千葉大院薬
-
萩原 秀美
Research Institute For Chemobiodynamics Chiba University
-
Yamazaki M
School Of Pharmaceutical Sciences Kinki University
関連論文
- Brazilian Natural Medicines. III. Structures of Triterpene Oligoglycosides and Lipase Inhibitors from Mate, Leaves of Ilex paraguariensis
- Medicinal Flowers. XXVI. Structures of Acylated Oleanane-Type Triterpene Oligoglycosides, Yuchasaponins A, B, C, and D, from the Flower Buds of Camellia oleifera : Gastroprotective, Aldose Reductase Inhibitory, and Radical Scavenging Effects
- Medicinal Flowers. XXI. : Structures of Perennisaponins A, B, C, D, E, and F, Acylated Oleanane-Type Triterpene Oligoglycosides, from the Flowers of Bellis perennis
- Medicinal Flowers. XXVII : New Flavanone and Chalcone Glycosides, Arenariumosides I, II, III, and IV, and Tumor Necrosis Factor-α Inhibitors from Everlasting, Flowers of Helichrysum arenarium
- Structures of Acetylated Oleanane-Type Triterpene Saponins, Rarasaponins IV, V, and VI, and Anti-hyperlipidemic Constituents from the Pericarps of Sapindus rarak
- Absolute Stereostructures of Olibanumols A, B, C, H, I, and J from Olibanum, Gum-Resin of Boswellia carterii, and Inhibitors of Nitric Oxide Production in Lipopolysaccharide-Activated Mouse Peritoneal Macrophages
- Medicinal Flowers. XXIV. Chemical Structures and Hepatoprotective Effects of Constituents from Flowers of Hedychium coronarium
- Medicinal Flowers. XXIII. New Taraxastane-Type Triterpene, Punicanolic Acid, with Tumor Necrosis Factor-α Inhibitory Activity from the Flowers of Punica granatum
- Bioactive Constituents from Chinese Natural Medicines. XXXII : Aminopeptidase N and Aldose Reductase Inhibitors from Sinocrassula indica: Structures of Sinocrassosides B_4, B_5, C_1, and D_1-D_3
- Medicinal Foodstuffs. XXXIV. : Structures of New Prenylchalcones and Prenylflavanones with TNF-α and Aminopeptidase N Inhibitory Activities from Boesenbergia rotunda
- Bioactive Constituents from Chinese Natural Medicines. XXVI : Chemical Structures and Hepatoprotective Effects of Constituents from Roots of Rhodiola sachalinensis
- Bioactive Constituents from Chinese Natural Medicines. XXIV. : Hypoglycemic Effects of Sinocrassula indica in Sugar-Loaded Rats and Genetically Diabetic KK-A^y Mice and Structures of New Acylated Flavonol Glycosides, Sinocrassosides A_1, A_2, B_1, and B_2
- クサウラベニタケの毒性成分の研究(第2報) : 溶血素の精製と溶血条件の検討
- クサウラベニタケの毒性成分の研究(第1報)生物活性と毒性成分の探索
- New Toxic Metabolites from a Mushroom, Hebeloma vinosophyllum. II. Isolation and Structures of Hebevinosides VI, VII, VIII, IX, X, and XI(Organic,Chemical)
- New Toxic Metabolites from a Mushroom, Hebeloma vinosophyllum. I. : Structures of Hebevinosides I, II, III, IV, and V
- 69 アカヒダワカフサタケの毒性代謝産物hebevinoside類の単離と構造(その2)
- 9 アカヒダワカフサタケの毒性代謝産物hebevinoside類の単離と構造
- THE TOXIC PRINCIPLES OF NAEMATOLOMA FASCICULARE
- Chemistry of Tremorogenic Metabolites. II. Structure Determination of Fumitremorgin B, a Tremorogenic Metabolite from Aspergillus fumigatus
- 78(P-35) 子嚢菌Chaetomium quadrangulatumのモノアミン酸化酵素阻害活性成分(ポスター発表の部)
- Apoptosis-Inducing Effects of Sterols from the Dried Powder of Cultured Mycelium of Cordyceps sinensis
- Application of High-Performance Liquid Chromatography Using Water-Containing Silica Gel Columns for Large-Scale Preparation of Cerebroside
- The Principles of Tetragonia tetragonoides having Anti-ulcerogenic Activity. II. Isolation and Structure of Cerebrosides
- STRUCTURE OF ED-1 ISOLATED FROM EMERICELLA DENTATA
- Isolation and Structures of Oxaphenalenone Dimers from Talaromyces bacillosporus
- Isolation of Some New Tryptoquivaline-related Metabolites from Aspergillus fumigatus
- Bioactive Constituents from Chinese Natural Medicines. XXIII. Absolute Structures of New Megastigmane Glycosides, Sedumosides A_4, A_5, A_6, H, and I, and Hepatoprotective Megastigmanes from Sedum sarmentosum
- Bioactive Constituents from Chinese Natural Medicines. XXII. Absolute Structures of New Megastigmane Glycosides, Sedumosides E_1, E_2, E_3, F_1, F_2, and G, from Sedum sarmentosum (Crassulaceae)
- Bioactive Saponins and Glycosides. XXVIII. New Triterpene Saponins, Foliatheasaponins I, II, III, IV, and V, from Tencha (the Leaves of Camellia sinensis)
- P-469 ANTI-ALLERGIC AND ANTI-INFLAMMATORY ACTIVITIES OF 1'S-1'-ACETOXYCHAVICOL ACETATE AND RELATED COMPOUNDS
- P-466 ACYLATED PHENETHYLGLYCOSIDES WITH VASORELAXANT ACTIVITY FROM CISTANCHE TUBULOSA
- P-298 SYNTHESIS OF 1,5-ANHYDRO-5-AZA-D-GLUCITOL ANALOGS OF SALACINOL AND THEIR α-GLUCOSIDASE INHIBITORY ACTIVITIES
- Monoterpene Constituents from Cistanche tubulosa : Chemical Structures of Kankanosides A-E and Kankanol
- Inhibitors of Nitric Oxide Production from the Rhizomes of Alpinia galanga : Structures of New 8-9' Linked Neolignans and Sesquineolignan
- Antidiabetogenic constituents from Salacia species(Chemical & Pharmacological study)
- Synthesis of a Nitrogen Analogue of Salacinol and Its α-Glucosidase Inhibitory Activity
- Saponins of Plants of Panax Species Collected in Central Nepal, and Their Chemotaxonomical Significance. III.
- Study on Anti-Oketsu Activity of Rhubarb II. Anti-allergic Effects of Stillbene Components from Rhei undulati Rhizoma(Dried Rhizome of Rheum undulatum Cultivated in Korea)
- Studies on Alismatis Rhizoma. III. Stereostructures of New Protostane-Type Triterpenes, Alisols H, I, J-23-Acetate, K-23-Acetate, L-23-Acetate, M-23-Acetate, and N-23-Acetate, from the Dried Rhizome of Alisma orientale
- Hepatoprotective and Antioxidative Properties of Salacia reticulata : Preventive Effects of Phenolic Constituents on CCl_4-Induced Liver Injury in Mice
- Medicinal Foodstuffs. XVIII. Phytoestrogens from the Aerial Part of Petroselinum crispum MILL. (PARSLEY) and Structures of 6"-Acetylapiin and a New Monoterpene Glycoside, Petroside
- Medicinal Flowers. II. Inhibitors of Nitric Oxide Production and Absolute Stereostructurs of Five New Germacrane-Type Sesquiterpenes, Kikkanols D, D Monoacetate, E, F, and F Monoacetate from the Flowers of Chrysanthemum indicum L.
- Chemical Constituents from the Leaves of Hydrangea macrophylla var. thunbergii(III) : Absolute Stereostructures of Hydramacrosides A and B, Secoiridoid Glucoside Complexes with Inhibitory Activity on Histamine Release
- The Role of Thunberginol A, an Isocoumarin Constituent of Hydrangeae Dulcis Folium, on the Signal Transmission Pathway for Rat Mast Cell Degranulation
- Effects of Phyllodulcin, Hydrangenol, and Their 8-O-Glucosides, and Thunberginols A and F from Hydrangea macrophylla SERINGE var. thunbergii MAKINO on Passive Cutaneous Anaphylaxis Reaction in Rats
- Medicinal Foodstuffs. XXIV.^ Chemical Constituents of the Processed Leaves of Apocynum venetum L. : Absolute Stereostructures of Apocynosides I and II
- Syntheses of Antifungal Isocoumarins. III. Synthesis and Antifungal Activity of 3-Aryl-3,4-dihydro-4-substituted-isocoumarins
- Antifungal Activity of Oosponol, Oospolactone, Phyllodulcin, Hydrangenol, and Some Other Related Compounds
- Syntheses of Antifungal Isocoumarins. II. Synthesis and Antifungal Activity of 3-Substituted Isocoumarins
- マイコトキシンの一種,デオキシニバレノールの土壌細菌による毒性低減化 : 微生物
- 111(P-58) 真菌由来α-ピロン環型天然物の立体化学(ポスター発表の部)
- 81(P-79) マユハキタケ科子嚢菌2種からの免疫調節活性成分の単離とその絶対配置(ポスター発表の部)
- 子嚢菌 Sordaria gondaensis の免疫抑制活性成分
- P-41 防風の鎮痛活性成分 II.
- 72(P47) Gelasinospora属子嚢菌3種からの免疫調節活性成分(ポスター発表の部)
- 子嚢菌 Emericella corrugata からの新毒性代謝産物
- 61(P31) 子嚢菌Diplogelasinospora grovesii及び関連菌からの新免疫抑制活性成分(ポスター発表の部)
- P-60 子嚢菌Gelasinospora multiforis及びG. kobiからの新免疫抑制活性成分(ポスター発表の部)
- Isolation of Some Immunosuppressive Components from an Ascomycete, Gelasinospora multiforis
- NEW FUNGAL METABOLITES AVELLANINS A AND B FROM HAMIGERA AVELLANEA, WITH PRESSOR EFFECT(Communication to the Editor)
- Four New Immunosuppressive Components, Kobiin and Kobifuranones A, B, and C, from an Ascomycete, Gelasinospora kobi
- 子のう菌 Talaromyces luteus より得られた新MAO阻害物質 Luteusin A と可逆的MAO-B阻害薬Ro16-6491との ex vivo におけるMAO阻害活性の比較検討
- Four New Chlorinated Azaphilones, Helicusins A-D, Closely Related to 7-epi-Sclerotiorin, from an Ascomycetous Fungus, Talaromyces helicus
- 子嚢菌 Gelasinospora pseudoreticulata 由来 Mycelia Sterilia からのモノアミン酸化酵素阻害活性成分
- Isolation and Characterization of Immunosuppressive Components of Three Mushrooms, Pisolithus tinctorius, Microporus flabelliformis and Lenzites betulina
- 38 子のう菌Talaromyces luteus、T. helicusより得られた新azaphilone代謝産物(口頭発表の部)
- Identification of Immunosuppressive Components of a Mushroom, Lactarius flavidulus
- Isolation, Identification and Pharmacological Studies on Three Toxic Metabolites from a Mushroom, Hebeloma spoliatum
- New Toxic Metabolites from a Mushroom, Hebeloma vinosophyllum. III. Isolation and Structures of Three New Glycosides, Hebevinosides XII, XIII and XIV, and Productivity of the Hebevinosides at Three Growth Stages of the Mushroom
- Biosynthesis of Silvaticamide, a Toxin from Aspergillus silvaticus
- Structure Determination of Violaceol-I and -II, New Fungal Metabolites from a Strain of Emericella violacea
- The Isolation and Structure Determination of Violaceic Acid, A New biphenyl Ether Type Metabolite from Emericella violacea
- The Absolute Configuration of Desacetylaustin isolated from Emericella nidulans var. dentata
- Isolation and Structure of Red Pigment from Aspergillus ochraceus WILH
- きのこの生理活性物質 (きのこの生物工学)
- 子嚢菌由来のxanthone系免疫抑制活性成分について (第14回天然薬物の開発と応用シンポジウム 講演要旨集) -- (一般講演 天然資源と医薬品開発2)
- Wrightiamines A and B, Two New Cytotoxic Pregnane Alkaloids from Wrightia javanica
- Analgesic Components of Saposhnikovia Root : Saposhnikovia divaricata
- Chemistry of Tremorogenic Metabolites. I. Fumitremorgin A from Aspergillus fumigatus
- Six New Constituents from an Ascomycete, Chaetomlum quadrangulatum, Found in a Screening Study Focused on Monoamine Oxidase Inhibitory Activity
- Monoamine Oxidase Inhibitory Naphthoquinone and/or Naphthalene Dimers from Lemuni Hitam (Diospyros sp.), a Malaysian Herbal Medicine
- Immunomodulatory Constituents from an Ascomycete, Microascus tardifaciens
- Immunomodulatory Constituents from Three Ascomycetes, Gelasinospora heterospora, G. multiforis, and G. longispora
- Manoamine Oxidase Inhibitory constituents from Anixiella micropertusa
- Immunosuppressive Components from an Ascomycete, Diplogelasinospora grovesii
- Isolation of New Tremorgenic Metabolites from an Ascomycete, Corynascus setosus
- REVISED STEREOSTRUCTURES OF LUTEUSINS C AND D
- Separation of Leucas aspera, a Medicinal Plant of Bangladesh, Guided by Prostaglandin Inhibitory and Antioxidant Activities
- Monoamine Oxidase-Inhibitory Components from an Ascomycete, Coniochaeta tetraspora
- Isolation of Three New Azaphilones, Luteusins C, D, and E, from an Ascomycete, Talaromyces luteus
- Five New Chromones Possessing Monoamine Oxidase Inhibitory Activity from an Ascomycete, Chaetomium quadrangulatum
- Novel Syntheses of Murrayaquinone A and Furostifoline through 4-Oxygenated Carbazoles by Allene-Mediated Electrocyclic Reactions Starting from 2-Chloroindole-3-carbaldehyde
- Six Immunosuppressive Features from an Ascomycete, Zopfiella longicaudata. Found in a Screening Study Monitored by Immunomodulatory Activity
- Immunomodulatory Constituents from an Ascomycete, Emericella aurantio-brunnea
- New Syntheses of Murrayaquinone A and Furostifoline
- Structure Determination of Six Fungal Metabolites, Tryptoquivaline E, F, G, H, I and J from Aspergillus fumigatus
- Structure of Tryptoquivaline C (FTC) and D (FTD). Novel Fungal Metabolites from Aspergillus fumigatus
- Analgesic Components of Glehnia Root (Glehnia littoralis)
- 子のう菌Talaromyces luteusより得られた新MAO阻害物質Luteusin Aと可逆的MAO-B阻害薬Ro16-6491とのex vivoにおけるMAO阻害活性の比較検討