Immunomodulatory Constituents from Three Ascomycetes, Gelasinospora heterospora, G. multiforis, and G. longispora
スポンサーリンク
概要
- 論文の詳細を見る
Three new 2-pyrones (2H-pyran-2-ones) called multiforisins G (3), H (1), and I (4), and a known hexaketide sordarial (2) have been isolated from an Ascomycete Gelasinospora heterospora. Among them, 1,2,and 3 have been proved to be the immunosuppressive components of the fungus. Compounds 1,3,and 4 have also been isolated from G.multiforis together with multiforisin A (5), which was formerly isolated from this fungus as its main immunosuppressive feature, and 1-5 have also been isolated from G. longispora. The absolute stereostructure of 2,which was not previously certain, has finally been determined to be (3'R, 4'S). It has been found that the multiforisins 1,3,and 5 in which one of the two substituents at positions 3 and 5 is a hydroxymethyl group and the other is a formyl or an acetoxymethyl group, show high immunosuppressive activity; the immunosuppressive activity of 3 does not seem to be due to inhibition of interleukin 2 (IL-2) production.
- 公益社団法人日本薬学会の論文
- 1999-01-15
著者
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山崎 幹夫
千葉大学薬学部
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藤本 治宏
千葉大院薬
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山崎 幹夫
千葉大学薬学部医薬品素材学講座
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奥山 恵美
千葉大学 院薬
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Natori Hiroko
Faculty Of Pharmaceutical Sciences Chiba University
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OKUYAMA Emi
Faculty of Pharmaceutical Sciences, Chiba University
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YAMAZAKI Mikio
Faculty of Pharmaceutical Sciences, Chiba University
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FUJIMOTO Haruhiro
Faculty of Pharmaceutical Sciences, Chiba University
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藤本 治宏
Chiba Univ. Chiba Jpn
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Okuyama Emi
Faculty Of Pharmaceutical Science Chiba University
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Sumino Megumi
Faculty Of Pharmaceutical Sciences Chiba University
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OKUYAMA Emi
Laboratory of Pharmacognosy, Faculty of Pharmaceutical Sciences, Josai International University
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NAGANO Junko
Faculty of Pharmaceutical Sciences, Chiba University
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Nagano Junko
Faculty Of Pharmaceutical Sciences Chiba University
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Okuyama E
Laboratory Of Pharmacognosy Faculty Of Pharmaceutical Sciences Josai International University
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Fujimoto Haruhiro
Faculty Of Pharmaceutical Sciences Chiba University
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Yamazaki Mikio
Faculty Of Pharmaceutical Sciences Chiba University
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