61(P31) 子嚢菌Diplogelasinospora grovesii及び関連菌からの新免疫抑制活性成分(ポスター発表の部)

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• On the last Symposium in 1995, we reported the isolation and structure elucidation of several immunosuppressive components, new α-pyrones named multiforisins A〜F from Gelasinospora multiforis and new 2-furanone derivatives tentatively named GK-2〜-5 (Chart1) from G.kobi except for GK-4. We report now the structure of the main immunosuppressive component of G.kobi, GK-4, and five immunosuppressive components tentatively named DG-1〜-5, which have newly been isolated from Diplogelasinospora grovesii, Chemical and spectroscopic investigation including application of the new Mosher's method indicated that the structure of GK-4 with absolute configuration was expressed to be 1, which was supposed to be a new macrocyclic sesterterpenetriol(see Chart 5). The structure of the main immunosuppressive principle of D.grovesii, DG-2, was elucidated to be a new a-pyrone derivative 9, mainly on the basis of its spectroscopic data. Other immunosuppressive principles of the fungus, DG-1, -3, -4, and -5 were also deduced to be a dimeric dilactone formed from two molecules of 3-hydroxybutyric acid (8), 10-epi-isomer of colletodiol(10), colletodiol(11), and isosclerone (12), respectively (see Chart 6,7,8).Among them,11 and 12 had been formerly isolated from Colletotrichum capsici and Sclerotinia sclerotiorum, respectively. Immunosuppressive activities evaluated with their IC_<50> values against mitogen-induced proliferations of mouse spleen lymphocytes of all of these fungal immunosuppressive components GK-2〜-5, DG-1〜-5 and their structure-immunosuppressive activity relationships were also discussed. We proposed to name GK-4 kobiin, GK-2, -3, and -5 kobifuranones A, B,and C, and DG-2 grovesiin, respectively.

• 天然有機化合物討論会の論文
• 1996-09-02

著者

• 山口 健太郎

  千葉大分析セ

• 山口 健太郎

  千葉大学分析センター

• 山崎 幹夫

  千葉大薬

• 山崎 幹夫

  千葉大学薬学部

• 藤本 治宏

  千葉大院薬

• 山崎 幹夫

  千葉大学薬学部医薬品素材学講座

• 佐藤 裕二

  千葉大薬

• 藤本 治宏

  千葉大薬

• 永野 順子

  千葉大薬

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