1,2,3-トリアジン誘導体の水素化ホウ素ナトリウムによる還元

スポンサーリンク

概要

• 論文の詳細を見る

• The reduction of substituted monocyclic 1,2,3-triazines with sodium borohydride in methanol afforded their 2,5-dihydro derivatives. The reduction of their 2-methyl quaternary salts also gave the 2,5-dihydro compounds. The reduction of their 1-oxides and 2-oxides yielded their deoxygenated products and 1,4,5,6-tetrahydro compounds, respectively. The same reaction of 1-methyl-2-oxo-triazinium salts afforded their 1,6-dihydro derivatives whose structures were elucidated by an X-ray crystallographic study.

• 社団法人日本薬学会の論文
• 1985-12-25

著者

• 山口 健太郎

  千葉大学分析センター

• 大沢 昭緒

  School of Pharmaceutical Sciences, Showa University

• 井下田 浩

  School of Pharmaceutical Sciences, Showa University

• 新井 平八郎

  Central Research Laboratories, Zeria Pharmaceutical Co., Ltd.,

• 伊藤 喬

  昭和大学薬学部

• 海宝 輝光

  School of Pharmaceutical Sciences, Showa University

• 大沢 昭緒

  昭和大学薬学部

• 新井 平八郎

  昭和大学薬学部

• 大西 英文

  昭和大学薬学部

• 海宝 輝光

  昭和大学薬学部

• 山口 健太郎

  昭和大学薬学部

• 井下田 浩

  昭和大学薬学部

• 飯高 洋一

  東京大学薬学部

• 伊藤 喬

  昭和大学薬学部薬化学教室

• 大沢 昭緒

  School Of Pharmaceutical Sciences Showa University

• 新井 平八郎

  Central Research Laboratories Zeria Pharmaceutical Co. Ltd.

• 海宝 輝光

  School Of Pharmaceutical Sciences Showa University

• 井下田 浩

  School Of Pharmaceutical Sciences Showa University

関連論文

• 97(P-10) Pandanus属植物含有新規ピロリジン型アルカロイドの構造決定とバイオミメティック全合成(ポスター発表の部)
• コールドスプレーイオン化質量分析
• 10 サフラマイシン系抗生物質の合成研究 : 光学活性サフラマイシンMx2の全合成(口頭発表の部)
• 3.新しいA修飾アナローダ,2α-置換-1,25-ジヒドロキシビタミンD_3 およびその20-エピマーのデザイン,合成,立体配座解析,および活性評価
• Flash Vacuum Pyrolysis of Aromatic Oximes
• Flash Vacuum Pyrolysis of 2-Picoline N-Oxide. Formation of 2-Picolyl Radical
• 2-I-15 レチノイン酸と蛍光性ジエノフィルとの位置選択的付加反応 : 第46回大会研究発表要旨
• 2 アミノ酸熱分解物中に含まれる変異原物質 : 分離・構造・合成および生物活性
• Synthesis of Prolyl Endopeptidase Inhibitors and Evaluation of Their Structure-Activity Relationships : In Vitro Inhibition of Prolyl Endopeptidase from Canine Brain
• 20-P3-545 医療系総合大学の特色を生かした昭和大学の医療人GP「チーム医療の有用性を実感する参加型学習」の取り組みと成果(薬学教育(その他),来るべき時代への道を拓く)
• 104(P-24) チオノペプチドを経由する抗腫瘍性環状ペプチドRA-VIIの化学修飾(ポスター発表の部)
• 107(P38) 抗腫瘍性環状ヘキサペプチドRA-VIIの骨格変換(ポスター発表の部)
• Lembehsterols A and B, Novel Sulfated Sterols Inhibiting Thymidine Phosphorylase, from the Marine Sponge Petrosia strongylata
• エレクトロスプレーイオン化質量分析
• P-57 New Zealand (NZ)産毒化貝中の新規水溶性神経毒の分離及び構造についての研究(ポスター発表の部)
• Study on the Bile Salt, Sodium Scymnol Sulfate, from Rhizoprionodon actuatus. II. The Structures of Scymnol, Anhydroscymnol and Sodium Scymnol Sulfate
• 17 毒化バイ貝Babylonia Japonicaよりの新有毒成分Neosurugatoxinの分離及び構造決定
• ISOLATION AND STRUCTURAL DETERMINATION OF MUTAGENIC SUBSTANCES IN COAL TAR
• ベンズアニリド及びN-メチルベンズアニリドの立体化学
• REACTION OF ORGANOMETALLIC REAGENTS WITH 2'- AND 3'-KETOURIDINE DERIVATIVES : SYNTHESIS OF URACIL NUCLEOSIDES BRANCHED AT THE 2'- AND 3'-POSITIONS(Communications to the Editor)
• Synthesis of 1,2,3-Triazine N-Oxides
• 1,2,3-トリアジン誘導体の水素化ホウ素ナトリウムによる還元
• THE STRUCTURE OF 1,2,3-TRIAZINE
• THE STRUCTURE OF 1,2,3-TRIAZINE
• ADDITION REACTION OF 1,2,3-TRIAZINE 2-IMINES WITH DIMETHYL ACETYLENEDICARBOXYLATE
• THE STRUCTURE AND ABSOLUTE CONFIGURATION OF HANAMISINE
• THE STRUCTURE AND ABSOLUTE CONFIGURATION OF SADOSINE
• THE STRUCTURE OF IGNAVINE
• A Potent Mutagen isolated from a Pyrolysate of L-Ornithine
• A Potent Mutagen isolated from a Pyrolysate of L-Ornithine
• Ultramicro Analysis of Benzo [α] pyrene in Food
• Revised Structure of N-Oxidation Products of 4,5,6-Triaryltriazines : 1,2,3-Triazine 2-Oxides
• The Degradation Pathway of 1,2,3,4-Tetrazine
• The Ring Transformation of 1,2,3-Triazines
• 1,2,3-トリアジン 2-イミンの合成, 構造及び反応
• 4,6-ジメチル-1,2,3-トリアジン 2-イミンの結晶構造
• Reactions of N-Aminopyrazoles with Halogenating Reagents and Synthesis of 1,2,3-Triazines
• ELECTRON IMPACT REACTOR FOR ORGANIC REACTIONS
• Design, Synthesis and Antiinflammatory Activity of a New Indomethacin Ester. 2-[N-[3-{3-(Piperidinomethyl)phenoxy}propyl]carbamoylmethylthio]ethyl 1-(p-Chlorobenzoyl)-5-methoxy-2-methylindole-3-acetate
• Studies on Pyridazines. X. Reactivity of 3-Hydroxypyridazine 1-Oxides. (2). Halogenation and Nitration of 3-Hydroxypyridazine 1-Oxides
• HALOGENATION OF 1,2,3-TRIAZINES
• REACTION OF 1,2,3-TRIAZINE WITH DIENOPHILES
• 質量分析の未来を語る
• 高速原子衝撃イオン化質量分析法における精密質量測定用標準物質の最適化
• Synthesis and Pharmacological Properties of N-[3-{3-(1-Piperidinylmethyl)phenoxy}propyl]-2-(2-hydroxyethylthio)acetamide and Related Compounds as Antiulcer Agents.I
• P-226 NOVEL POLYKETIDES, SHIMALACTONES A AND B, FROM A MARINE-DERIVED FUNGUS EMERICELLA VARIECOLOR GF10
• 1,3-Dipolar Cycloaddition of Pyridazinium Ylides with Perhalocycloalkenes and Thermal Decomposition of the Adducts
• Synthesis of 3-(Dialkylamino) indolizines. Reaction of 3-(2-Pyridyl)-2-propenals with Secondary Amines
• Thermal Decomposition of 2H-[1,2,4] Oxadiazolo [2,3-a] pyridine-2-thione and 2H-[1,2,4] Oxadiazolo [2,3-b] pyridazine-2-thiones : Generation of Aza-heteroaromatic α-Isocyanates and Their Utilization for the Synthesis of Unsymmetrical Disubstituted Ureas
• Alkynylation of Halopyridazines and Their N-Oxides
• Metalation of Alkylpyridazines. III. Nucleophilic Addition of Lithiated Methylpyridazines and Properties of the Adducts under Basic and Neutral Conditions
• Cross-Coupling Reaction of Chloropyridazines and Grignard Reagents with Nickel-phosphine Complexes : Alkylation and Arylation of Pyridazines
• Metalation of Alkylpyridazines. I. Alkylation of Metalated Alkylpyridazines with Alkyl Halides
• Studies on Diazepines. VI. Photolysis of 1H-1,2-Diazepine and Azepine Epidioxides
• Studies on Pyridazines. XXIII. Synthesis of N-Substituted 1,4-Dihydropyridazines
• Photo-oxygenation of 1H-1,2-Diazepine and Azepine Derivatives : Formation and Some Reactions of Their Epidioxides
• Studies on Pyridazines. XXVI. The Reaction of Substituted N-Acetyliminopyridazinium Ylides with Benzyne
• Studies on Pyridazines. XXIV. The Reaction of Pyridazine N-Oxides and Pyridazinium Ylides with Benzyne
• Photochemistry. XII. Photochemical Behavior of 2-Methyl-3 (2H)-pyridazinone 1-Oxides
• Photochemistry. XI. Photochemical Ring Contraction of 3 (2H)-Pyridazinones to 1-Amino-Δ^3-pyrrolin-2-ones
• Photochemistry. X. Photolysis of Tetrazolo [1,5-b] pyridazines
• A Photochemical Preparation of N-Substituted Pyrroles from Pyridazine N-Oxides
• Photochemistry. VII. Photolyses of Polyphenylpyridazine N-Oxides
• Photochemistry. VI. Photo-induced Methylation of Pyridazines
• Metalation of Alkylpyridazines. II. Acylation of Metalated Methylpyridazines and Isomeric Character of Acylmethylpyridazines
• Bio-organic synthesis of a newly isolated peptide metastin
• Synthesis of New Peptides, Apelin and Galanin-Like Peptide, by a Combination of Recombinant DNA Technology and Chemical Cleavage Reaction
• Synthesis of New Peptides with Prolactin-releasing Activity by a Combination of Recombinant DNA Technology and a Cysteine-specific Cyanylation Reaction
• Synthesis of New Peptides with Prolactin-releasing Activity by a Combination of Recombinant DNA Technology and a Cysteine-specific Cyanylation Reaction
• Renaturation of Recombinant Human Neurotrophin-3 from Inclusion Bodies
• 12 ヒンバシン類縁体の合成とそのムスカリンM_2サブタイプ受容体拮抗作用(口頭発表の部)
• 72(P47) Gelasinospora属子嚢菌3種からの免疫調節活性成分(ポスター発表の部)
• 20-P1-016 エパデールSでのポリスチレン溶解現象と分析及びポリスチレンを溶解する他の薬剤例 : 薬剤の懸濁に用いる器具の材質への注意(調剤・処方鑑査(内用薬),来るべき時代への道を拓く)
• THE SYNTHESIS OF 5-SUBSTITUTED 1,2,3,-TRIAZINES WITH KETENE SILYL ACETALS AND CERIC AMMONIUM NITRATE
• 1,2,3-トリアジン
• Reaction of Six-Membered Azaaromatics with Allyltributyltin
• THE REACTION OF 1-ETHOXYCARBONYL-3-METHYLBENZIMIDAZOLIUM SALTS WITH ELECTROGENERATED AND POTASSIUM SUPEROXIDE
• Vicarious Nucleophilic Substitution of Pyridines and 1,2,3-Triazines via Their Dicyanomethylide Derivatives
• VICARIOUS NUCLEOPHILIC SUBSTITUTION OF PYRIDINES VIA THEIR DICYANOMETHYLIDE DERIVATIVES
• The Reactions of 2-Methyl-1,2,3-triazinium Iodides and Related Compounds
• 19 スルホン酸基を含まない食用色素と塩酸アンブロキソールとの塩の形成
• 61(P31) 子嚢菌Diplogelasinospora grovesii及び関連菌からの新免疫抑制活性成分(ポスター発表の部)
• Electrooxidation of N-Aminopyrazoles
• Studies on Pyridazines. XI. Reactivity of 3-Hydroxypyridazine 1-Oxides. (3). Nuclear Magnetic Resonance Studies of 3-Hydroxypyridazine 1-Oxide and Its Derivatives
• 生体分子のマス・スペクトロメトリー : 田中氏の開発したMALDI及びESIなどのソフトイオン化を中心として
• コールドスプレー質量分析法の開発
• 複素還化合物を中心としたX線結晶解析の有機化学への貢献
• 生体高分子の質量分析
• 衛生化学領域における分析技術の最近の進歩シリーズVII液体クロマトグラフ質量分析計(LC-MS)による有機分析の進歩
• マススペクトロメトリーの最近の進歩
• A New Synthesis of 24-Fluoro-1α, 25-dihydroxyvitamin D_2 and Its 24-Epimer, and Determination of the C-24 Configuration
• 3,3'-Bipyridazine Derivatives as Spectrophotometric Reagents for Iron. II
• Photochemistry. IV. Photolyses of 3-Chloro-and 3-Hydroxy-6-phenylpyridazines in Methanol Containing Hydrogen Chloride
• Photochemistry. V. Photocyclization of 3,4,6-Tri- and 3,4,5,6- Tetraphenylpyridazines. Formation of 1,2-Diazapolyarenes
• Photochemistry. II. Formation of Methyl Paraconates and Dimethyl Succinates from Pyridazines
• Photo-induced Oxygenation of Hydrocarbons by Pyridazine N-oxides
• Studies on Pyridazines. XXI. Reaction of 1-Methylpyridazinium Salts with Potassium Cyanide
• Studies on Pyridazines.XX. Syntheses of 1,2-Bis(3'-pyridazinyl)-ethenes, -ethanes, and Their Di-N-oxides
• Studies on Hydrogen Exchange. VIII. The Basecatalysed Hydrogen Exchange of Methyl Hydrogens of Methylpyridazines and Their N-Oxides.
• ラット肝臓中の亜セレン酸代謝物の特徴付け

もっと見る 閉じる

スポンサーリンク