Thermal Decomposition of 2H-[1,2,4] Oxadiazolo [2,3-a] pyridine-2-thione and 2H-[1,2,4] Oxadiazolo [2,3-b] pyridazine-2-thiones : Generation of Aza-heteroaromatic α-Isocyanates and Their Utilization for the Synthesis of Unsymmetrical Disubstituted Ureas

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概要

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• Thermal decomposition of 2H-[1,2,4] oxadiazolo [2,3-a] pyridine-2-thione afforded 3-(2-pyridyl)-2H-pyrido [1,2-a]-1,3,5-triazine-2,4 (3H)-dione and 1,3-di (2-pyridyl) urea, and similar decomposition of its pyridazine analog afforded 3-(3-pyridazinyl)-2H-pyridazino [1,6-a]-1,3,5-triazine-2,4 (3H)-dione and 1,3-di (3-pyridazinyl) urea. Aza-heteroaromatic α-isocyanates, which are intermediates in the decomposition, were utilized for the synthesis of unsymmetrical 1,3-disubstituted ureas.

• 社団法人日本薬学会の論文
• 1980-12-25

著者

• 大沢 昭緒

  School of Pharmaceutical Sciences, Showa University

• 井下田 浩

  School of Pharmaceutical Sciences, Showa University

• 新井 平八郎

  Central Research Laboratories, Zeria Pharmaceutical Co., Ltd.,

• 新井 平八郎

  School of Pharmaceutical Sciences, Showa University

• 大沢 昭緒

  School Of Pharmaceutical Sciences Showa University

• 新井 平八郎

  Central Research Laboratories Zeria Pharmaceutical Co. Ltd.

• 井下田 浩

  School Of Pharmaceutical Sciences Showa University

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