Studies on Pyridazines.XX. Syntheses of 1,2-Bis(3'-pyridazinyl)-ethenes, -ethanes, and Their Di-N-oxides

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概要

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• The compounds, in which two pyridazine rings are combined through two carbon atoms, were synthesized. 3-Methylpyridazine 2-oxide (I) was condensed with 3-formylpyridazine 2-oxide (II) to give 1,2-bis[3'-(2'-oxido)-pyridazinyl]-ethene (III). Reaction of III with PCl_3 in CHCl_3 afforded the deoxygenated compound, 1,2-dis(3'-pyridazinyl)-ethene (IV). Oxidation of IV with H_2O_2 in AcOH gave 1'1'-di-N-oxide (V). Catalytic hydrogenation of III with Pd-C afforded 1,2-bis(3'-pyridazinyl)-ethane (VI). Oxidation of VI afforded three kinds of di-N-oxides, i.e., 1', 1'-di-N-oxide (VII), 1', 2'-di-N-oxide (VIII), and 2', 2'-di-N-oxide (IX). Wurtz's reaction of chloromethylpyridazines was also carried out, affording the corresponding ethane (XI) and ethene (XII) derivatives.

• 公益社団法人日本薬学会の論文
• 1973-01-25

著者

• 井下田 浩

  School of Pharmaceutical Sciences, Showa University

• 土屋 隆

  School of Pharmacy, Hokuriku University

• 井下田 浩

  School Of Pharmaceutical Sciences Showa University

• 鈴木 幸子

  School Of Pharmaceutical Sciences Showa University

• 土屋 隆

  Faculty Of Pharmaceutical Sciences Hokuriku University

• 金子 千里

  School of Pharmaceutical Sciences, Showa University

• 金子 千里

  Research Laboratory, Minophagen Pharmaceutical Co.,

• 金子 千里

  Research Laboratory Minophagen Pharmaceutical Co.

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