Studies on Diazepines. XV. Photolysis of Thieno-, Furo-, and Pyrrolo-[b] pyridine N-Imides : Formation of Fused 1H-1,2- and 3H-1,3-Diazepines

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概要

• 論文の詳細を見る

• Irradiation of the 2-methylpyridine N-acylimides (12b-d and 17a-c) condensed with a thiophene, furan, or pyrrole ring on the b-side of the pyridine ring gave the corresponding fused 1H-1,2-(13b-d and 18a-c) and 3H-1,3-diazepines (14b-d and 19a-c), together with the parent fused pyridines (10 and 15a-c), whereas the N-unsubstituted N-imide (12a) gave only the 1H-1,2-diazepine (13a) and no 1,3-diazepine. In this ring-expansion reaction, the initial photo-induced rearrengement may take place on either side of the pyridine nitrogen to give two kinds of diaziridine intermediates (21) and (22) ; the former may give 1,2-diazepines directly, whereas the latter may further rearrange to the aziridine intermediate (23), followed by ring-expansion to give the 1,3-diazepines. Some reactions of the new diazepines thus obtained were also examined.

• 公益社団法人日本薬学会の論文
• 1981-11-25

著者

• 岡島 悟

  School Of Pharmacy Hokuriku University

• 岡島 悟

  ヤクルト本社中央研究所

• 土屋 隆

  School of Pharmacy, Hokuriku University

• 円角 美智子

  School of Pharmacy, Hokuriku University

• 土屋 隆

  Faculty Of Pharmaceutical Sciences Hokuriku University

• 円角 美智子

  School Of Pharmacy Hokuriku University

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