Studies on Pyridazines. XV. N-Oxidation of 3,3'-Bipyridazines and Reactions of Their N-Oxides

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概要

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• N-Oxidation of 3,3'-bipyridazines (I, X, XXV) was carried out to form the corresponding N-oxides (II, III, XI, and XII). Reaction of the bipyridazines (I, X, and XX) with POCl_3-PCl_5 afforded the corresponding trichloromethyl compounds (VIII, and XXV) from I and XX, and the polychloro compounds (XVIII, and XIX), in which the chlorine atoms were substituted in the rings, from X. Treatment of the bipyridazine N-oxides (II, III, and XXI) with POCl_3,which have methyl groups α or γ-positions to the N-oxide groups, gave the corresponding chloromethyl compounds (VI, VII, and XXIII). And the reaction of the bipyridazine N-oxides (II and V) with Ac_2O afforded the corresponding acetoxy compounds (IV and III). In conclusion, the pattern of reactions of the 3,3'-bipyridazines and their N-oxides seems to be approximately analogous to that of monomeric pyridazines and their N-oxides.

• 社団法人日本薬学会の論文
• 1970-07-25

著者

• 井下 田浩

  School of Pharmaceutical Sciences, Showa University

• 土屋 隆

  Faculty of Pharmaceutical Sciences, Hokuriku University

• 土屋 隆

  School of Pharmacy, Hokuriku University

• 井下 田浩

  School Of Pharmaceutical Sciences Showa University

• 奥田 千里

  School of Pharmaceutical Sciences, Showa University

• 横川 秀晴

  School of Pharmaceutical Sciences, Showa University

• 奥田 千里

  School Of Pharmaceutical Sciences Showa University

• 横川 秀晴

  School Of Pharmaceutical Sciences Showa University

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