Studies on Seven-Membered Heterocycles.XXXI. : Synthesis of 1,4-Oxazepinones and 1,4-Diazepinones from 2-Pyridones and Their Conversion into Fully Unsaturated 1,4-Oxazepines and 1,4-Diazepines

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概要

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• Thermolysis of the 6-aza-3-oxatricyclo[3.2.0.0^<2,4>]heptan-7-ones(8 and 21) and 3,6-diazatricyclo[3.2.0.0^<2,4>]heptan-7-ones (9 and 22), prepared from the corresponding 2-pyridones (5) via the 2-azabicyclo[2.2.0]hex-5-en-3-ones (7 and 18), resulted in valence isomerization with ring opening to give the novel 1,4-oxazepin-5-ones (10a-e and 15a-c) and 1,4-diazepin-5-ones (11a-e and 16a-c), respectively. Treatment of the N-unsubstituted compounds 15 and 16 with triethyloxonium tetrafluoroborate afforded the fully unsaturated 1,4-oxazepines (23a-c) and 1H-1,4-diazepines (24a-c), respectively.

• 1990-11-25

著者

• 米田 剛治

  Faculty Of Pharmaceutical Sciences Hokuriku University

• 土屋 隆

  Faculty of Pharmaceutical Sciences, Hokuriku University

• 栗田 城治

  Faculty of Pharmaceutical Sciences, Hokuriku University

• 角沢 直紀

  Faculty of Pharmaceutical Sciences, Hokuriku University

• 土屋 隆

  Faculty Of Pharmaceutical Sciences Hokuriku University

• 角沢 直紀

  Faculty Of Pharmaceutical Sciences Hokuriku University

• 栗田 城治

  Faculty Of Pharmaceutical Sciences Hokuriku University

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